QUANTITATIVE-ANALYSIS OF THE 24-HOUR BLOOD-PRESSURE AND HEART-RATE PATTERNS IN YOUNG MEN
QUANTITATIVE-ANALYSIS OF THE 24-HOUR BLOOD-PRESSURE AND HEART-RATE PATTERNS IN YOUNG MEN
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DOI：
10.1161/01.hyp.18.2.199
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发表时间：
1991-08-01
期刊：
影响因子：
8.3
通讯作者：
VANCAUTER, E
中科院分区：
文献类型：
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作者：
DEGAUTE, JP;VANDEBORNE, P;VANCAUTER, E
为了描述正常的昼夜血压和心率曲线，并描述睡眠和昼夜节律的相对作用，我们对31名健康年轻男性进行了24小时动态血压监测，同时进行多导睡眠记录，并在标准化的身体和社会环境中进行了调查。在连续4个晚上进行脑电图睡眠记录。从记录的第四个晚上之前的早晨开始，每10分钟测量一次血压和心率，持续24小时。睡眠质量没有显着改变动态血压监测。使用基于周期图方法的最佳拟合曲线来量化24小时周期内血压和心率的变化。典型的血压和心率模式是双峰的，具有早晨峰值（大约10：00 AM），下午小的最低点（大约3：00 PM），晚上峰值（大约8：00 PM）和深夜最低点（大约3：00 AM）。昼夜变化的幅度最大的心率，中间的舒张压，最小的收缩压（分别为19.9%，14.1%，10.9%的24小时平均值）。在醒来之前，血压和心率已经显著增加。卧位和睡眠占夜间血压下降的65-75%，但它只能解释夜间心率下降的50%。因此，姿势变化和觉醒-睡眠过渡的综合影响是血压24小时节律的主要因素。相比之下，24小时心率节律可能反映了内源性昼夜节律，并被睡眠的影响放大。我们的结论是，调节因素不同的控制nycterohemeral血压的变化影响24小时的心率变化。
To characterize the normal nycterohemeral blood pressure and heart rate profiles and to delineate the relative roles of sleep and circadian rhythmicity, we performed 24-hour ambulatory blood pressure monitoring with simultaneous polygraphic sleep recording in 31 healthy young men investigated in a standardized physical and social environment. Electroencephalographic sleep recordings were performed during 4 consecutive nights. Blood pressure and heart rate were measured every 10 minutes for 24 hours starting in the morning preceding the fourth night of recording. Sleep quality was not significantly altered by ambulatory blood pressure monitoring. A best-fit curve based on the periodogram method was used to quantify changes in blood pressure and heart rate over the 24-hour cycle. The typical blood pressure and heart rate patterns were bimodal with a morning acrophase (around 10:00 AM), a small afternoon nadir (around 3:00 PM), an evening acrophase (around 8:00 PM), and a profound nocturnal nadir (around 3:00 AM). The amplitude of the nycterohemeral variations was largest for heart rate, intermediate for diastolic blood pressure, and smallest for systolic blood pressure (respectively, 19.9%, 14.1%, and 10.9% of the 24-hour mean). Before awakening, a significant increase in blood pressure and heart rate was already present. Recumbency and sleep accounted for 65-75% of the nocturnal decline in blood pressure, but it explained only 50% of the nocturnal decline in heart rate. Thus, the combined effects of postural changes and the wake-sleep transition are the major factors responsible for the 24-hour rhythm in blood pressure. In contrast, the 24-hour rhythm of heart rate may reflect an endogenous circadian rhythm, amplified by the effect of sleep. We conclude that modulatory factors different from those controlling nycterohemeral changes in blood pressure influence the 24-hour variation in heart rate.