Diet-induced hyperphagia in the rat is influenced by sex and exercise
Diet-induced hyperphagia in the rat is influenced by sex and exercise
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DOI：
10.1152/ajpregu.00424.2004
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发表时间：
2004-11-01
影响因子：
2.8
通讯作者：
Moore, SR
中科院分区：
文献类型：
--
作者：
Eckel, LA;Moore, SR
在喂食比实验室食物含有更多脂肪或糖的饮食的大鼠中，卡路里摄入量增加。由于这种饮食诱导的摄食过多主要是在久坐的雄性大鼠中研究的，因此我们的目标是研究性别和运动对饮食（补充甜牛奶的食物）的热量摄入的影响，所选择的饮食具有刺激摄食过多的能力。将大鼠单独圈养在提供运行轮的笼中，并在久坐和活动条件下监测单独食物以及随后食物加甜牛奶的每日热量摄入。在久坐大鼠中，雄性大鼠的食物摄入量高于雌性大鼠。车轮运行产生类似的减少食物摄入量在两种性别。与普通饲料喂养的大鼠相比，普通饲料加牛奶饮食的可用性增加了热量摄入。相对于久坐不动的雄性动物（增加9.1+/-2.2%），久坐不动的雌性动物（增加35.7+/-3.1%）的饮食诱导的摄食量显著更大。此外，35%的久坐不动的女性消费的食物加牛奶的饮食发展发情周期中断。车轮运行减少摄入的食物加牛奶的饮食在两种性别。在活跃的雄性动物中，消除了饮食诱导的摄食过多;热量摄入减少至饲料喂养期间观察到的水平。在活跃的雌性大鼠中，饮食诱导的摄食过多减弱但未消除;食物加牛奶饮食的热量摄入仍大于食物喂养期间观察到的热量摄入。我们的结论是，雌性大鼠比雄性大鼠更容易受到这种形式的饮食诱导的暴食症。
Caloric intake is increased in rats fed a diet containing greater fat or sugar than that found in laboratory chow. Because such diet-induced hyperphagia has been studied primarily in sedentary male rats, our goal here was to investigate the effects of sex and exercise on caloric intake of a diet ( chow supplemented with sweet milk) chosen for its ability to stimulate hyperphagia. Rats were housed individually in cages that provided access to running wheels, and daily caloric intake of chow alone and then chow plus sweet milk was monitored during sedentary and active conditions. In sedentary rats, chow intake was greater in males compared with females. Wheel running produced similar decreases in chow intake in both sexes. Availability of the chow plus milk diet increased caloric intake compared with that observed in chow-fed rats. This diet-induced hyperphagia was significantly greater in sedentary females (35.7+/-3.1% increase) relative to sedentary males (9.1+/-2.2% increase). In addition, 35% of sedentary females consuming the chow plus milk diet developed estrous cycle disruptions. Wheel running decreased intake of the chow plus milk diet in both sexes. In active males, diet-induced hyperphagia was abolished; caloric intake was reduced to that observed during chow feeding. In active female rats, diet-induced hyperphagia was attenuated but not abolished; caloric intake of the chow plus milk diet remained greater than that observed during chow feeding. We conclude that female rats are more vulnerable than male rats to this form of diet-induced hyperphagia.