Ten-year mortality and glucose tolerance status in an elderly Finnish population
Ten-year mortality and glucose tolerance status in an elderly Finnish population
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DOI：
10.1016/j.diabres.2004.11.004
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发表时间：
2005-07-01
影响因子：
5.1
通讯作者：
Hiltunen, L
中科院分区：
文献类型：
--
作者：
Hiltunen, L
本研究的目的是参考葡萄糖耐量状态，同时考虑超额死亡率的其他决定因素，确定 70 岁或以上老年人群 (n = 379) 的 10 年死亡率。 1991-1992年基线检查包括邮寄问卷、体格检查和2 h OGTT，按1985年WHO标准和1999年WHO标准分类。随访一直持续到死亡或2001年12月31日。66%的男性和51%的女性在10年内死亡。在男性中，先前诊断的糖尿病的累积死亡率为 84%，未诊断的糖尿病的累积死亡率为 67%，糖耐量受损 (IGT) 的累积死亡率为 67%，糖耐量正常 (NGT) 的累积死亡率为 60%。女性的相应比例分别为 76%、52%、49% 和 40%。男性、自评健康状况不佳和既往诊断出糖尿病是死亡率最有力的预测因素。当对年龄、性别、BMI、心血管疾病、高血压、体育锻炼和自评健康状况进行调整后，与 NGT 受试者相比，既往诊断的糖尿病受试者的估计相对死亡率为 2.0 (95% CI 1.5-2.7)，未诊断的糖尿病受试者的估计相对死亡率为 1.3 (CI 0.8-2.2)，IGT 受试者的估计相对死亡率为 1.1 (0.8-1.5)。女性的相对死亡率高于男性。当异常糖耐量合并为一类时，超额死亡率的 OR 为 1.4 (95% CI 1.1-1.9)。 (c) 2004 Elsevier Ireland Ltd. 保留所有权利。
The aim of this study was to determine the 10-year mortality rate of an elderly population aged 70 years or over (n = 379) with reference to glucose tolerance status, taking into account other determinants of excess mortality. The baseline examination during 1991-1992 included a postal questionnaire, a physical examination and a 2 h OGTT, which was classified according to both the 1985 WHO criteria and the 1999 WHO criteria. Follow-up was continued until death or until 31 December 2001. 66% of men and 51% of women died within 10 years. In men, the cumulative mortalities were 84% for previously diagnosed diabetes, 67% for undiagnosed diabetes, 67% for impaired glucose tolerance (IGT) and 60% for normal glucose tolerance (NGT). The corresponding percentages for women were 76, 52, 49, and 40%. Male gender, poor self-rated health and previously diagnosed diabetes were the most powerful predictors of mortality. When adjustments were made for age, gender, BMI, cardiovascular disease, hypertension, physical exercise and self-rated health, the estimated relative mortality rate was 2.0 (95% Cl 1.5-2.7) among previously diagnosed diabetic subjects, 1.3 (CI 0.8-2.2) among undiagnosed diabetic subjects and 1.1 (0.8-1.5) among IGT subjects compared to NGT subjects. These relative mortalities were higher in women than in men. When abnormal glucose tolerance was pooled into one category, the OR for excess mortality was 1.4 (95% CI 1.1-1.9). (c) 2004 Elsevier Ireland Ltd. All rights reserved.