Occurrence of a tetrodotoxin-associated substance in a gastropod, "hanamushirogai" Zeuxis siquijorensis.
Occurrence of a tetrodotoxin-associated substance in a gastropod, "hanamushirogai" Zeuxis siquijorensis.
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腹足动物“hanamushirogai”Zeuxis siquijorensis 中存在河豚毒素相关物质。
DOI：
10.2331/suisan.50.85
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发表时间：
1984
影响因子：
0.4
通讯作者：
K. Hashimoto
中科院分区：
文献类型：
--
作者：
H. Narita;T. Noguchi;J. Maruyama;M. Nara;K. Hashimoto
从清水沿海采集的腹足类“hanamushiRogai”Zeuxis siquijorensis中检测到一种麻痹毒素。通过河豚毒素(TTX)的纯化方法，对毒素进行了部分纯化，并与TTX的正品进行了比较。“花木香”毒素与河豚毒素在薄层层析和电泳谱上均有明显不同。它们在小鼠体内的剂量-死亡时间曲线并不重叠。但经GC-MS分析证明，“华南星”毒素在碱性条件下可产生C9碱基(2-amino-6-hydroxymethy1-8-hydroxyquinazoline)。结果表明，该毒素与TTX一样，是一种含有喹唑啉骨架(C9碱基)的TTX相关物质。
A paralytic toxin was detected in a gastropod, “hanamushirogai” Zeuxis siquijorensis collected from the coast of Shimizu. The toxin was partially purified, essentially by a purification method of tetrodotoxin (TTX), and compared with an authentic specimen of TTX. “Hanamushirogai” toxin clearly differed from TTX in both thin-layer chromatographic and electrophoretic behaviors. Their dose-death time curves in mice did not superimpose on each other. However, it was demonstrated by GC-MS that “hanamushirogai” toxin gives rise to C9-base (2-amino-6-hydroxymethy1-8-hydroxyquinazoline) when hydrolyzed with alkali. It was concluded from these results that the toxin is a TTX-associated substance which contains the quinazoline skeleton (C9-base) as does TTX.