Predictive value of prehypertension for metabolic syndrome, diabetes, and coronary heart disease among Turks
Predictive value of prehypertension for metabolic syndrome, diabetes, and coronary heart disease among Turks
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DOI：
10.1038/ajh.2008.212
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发表时间：
2008-08-01
影响因子：
3.2
通讯作者：
Hergenc, Gulay
中科院分区：
文献类型：
--
作者：
Onat, Altan;Yazici, Mehmet;Hergenc, Gulay
研究背景高血压前期的预测因子及其在预测代谢综合征（MetS）、2型糖尿病（DM）和冠心病（CHD）中的意义尚需进一步探讨。（血压（BP）120-139收缩压或80-89 mm Hg舒张压）在土耳其成年人的代表性样本中进行了前瞻性研究。501名男性和1，533名女性在基线时为48 12岁。高血压前期，确定在32.8%的样本，不同于正常血压组主要是年龄调整的肥胖措施和C-反应蛋白（CRP），并进展为高血压的两倍以上的年发病率为正常血压。在logistic回归分析中，校正性别、年龄、心率和吸烟状况后，与血压正常者相比，高血压前期对男性和女性MetS的风险均有预测作用（相对风险（RR）1.55（95%可信区间（CI）1.21; 1.99））。然而，仅在女性中，高血压前期对糖尿病和冠心病有显著的预测作用（RR分别为2.06和1.98）。女性的心脏代谢风险在很大程度上与肥胖无关。体重指数（BMI）在基线预测显着随后发展的新的高血压前期在两种性别（危害比1.39（95%CI 1.17; 1.65））和CRP往往有助于这种risk.CONCLUSIONSPrehypertension，与normotension相比，约一倍的风险，糖尿病，代谢综合征，冠心病的女性没有赋予实质性的风险，在土耳其男性，除了对代谢综合征。女性高血压前期的过度心脏代谢风险与肥胖无关。BMI是高血压前期的决定因素。
BACKGROUNDPredictors of prehypertension and the latter's significance in predicting metabolic syndrome (MetS), type 2 diabetes (DM), and incident coronary heart disease (CHD) need further exploration.METHODSIndividuals with or without prehypertension (blood pressure (BP) 120-139 systolic or 80-89 mm Hg diastolic) were studied prospectively in a representative sample of Turkish adults.RESULTSMean age of 1,501 men and 1,533 women was 48 12 years at baseline. Prehypertension, identified in 32.8% of the sample, differed from the normotensive group mainly by age-adjusted obesity measures and C-reactive protein (CRP) and progressed to hypertension at more than twofold annual incidence as normotension did. In logistic regression analysis, adjusted for sex, age, heart rate, and smoking status, prehypertension waspredictive for risk of MetS in both genders (relative risk (RR) 1.55 (95% confidence interval (CI) 1.21; 1.99)) compared with normotensives. However, DM and CHD were significantly predicted by prehypertension only in women (RR 2.06 and 1.98, respectively, for outcomes). Cardiometabolic risks in women were largely independent of obesity. Body mass index (BMI) at baseline predicted significantly subsequent development of new prehypertension in both genders (hazard ratio 1.39 (95% Cl 1.17; 1.65)) and CRP tended to contribute to this risk.CONCLUSIONSPrehypertension, compared with normotension, approximately doubles the risk for DM, MetS, and CHD in women without conferring substantial risk in Turkish men, except toward MetS. Excess cardiometabolic risk of prehypertension in women is independent of obesity. BMI is a determinant of prehypertension.