CCN: core regulatory proteins in the microenvironment that affect the metastasis of hepatocellular carcinoma?
CCN: core regulatory proteins in the microenvironment that affect the metastasis of hepatocellular carcinoma?
复制标题
CCN：微环境中影响肝细胞癌转移的核心调控蛋白？
DOI：
10.18632/oncotarget.6209
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发表时间：
2016-01-12
期刊：
影响因子：
--
通讯作者：
Qin L
中科院分区：
文献类型：
--
作者：
Jia Q;Dong Q;Qin L
肝细胞癌（HCC）是一种潜在的慢性肝脏炎症性疾病，如慢性乙型肝炎或丙型肝炎病毒感染，由于HCC转移的高频率，HCC患者的一般预后仍然非常糟糕。在肿瘤转移的整个过程中，肿瘤细胞不断与周围微环境交流，改善其恶性表型。因此，靶向肿瘤微环境作为HCC治疗的主要治疗方法是有充分理由的。最近，CCN家族蛋白在炎症微环境中作为局部多任务信号整合体出现。在这篇综述中，我们总结了CCN家族蛋白在炎症和肿瘤中的最新知识。我们还提出CCN家族蛋白可能在肿瘤微环境信号传导和肝癌转移调控中发挥核心作用。
Hepatocellular carcinoma (HCC) results from an underlying chronic liver inflammatory disease, such as chronic hepatitis B or C virus infections, and the general prognosis of patients with HCC still remains extremely dismal because of the high frequency of HCC metastases. Throughout the process of tumor metastasis, tumor cells constantly communicate with the surrounding microenvironment and improve their malignant phenotype. Therefore, there is a strong rationale for targeting the tumor microenvironment as primary treatment of HCC therapies. Recently, CCN family proteins have emerged as localized multitasking signal integrators in the inflammatory microenvironment. In this review, we summarize the current knowledge of CCN family proteins in inflammation and the tumor. We also propose that the CCN family proteins may play a central role in signaling the tumor microenvironment and regulating the metastasis of HCC.