Serum retinol binding protein 4 is related to insulin resistance and nonoxidative glucose metabolism in lean and obese women with normal glucose tolerance
Serum retinol binding protein 4 is related to insulin resistance and nonoxidative glucose metabolism in lean and obese women with normal glucose tolerance
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DOI：
10.1210/jc.2008-0077
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发表时间：
2008-07-01
影响因子：
5.8
通讯作者：
Gorska, Maria
中科院分区：
文献类型：
--
作者：
Kowalska, Irina;Straczkowski, Marek;Gorska, Maria
背景：视黄醇结合蛋白（RBP）4由脂肪组织分泌，被认为是胰岛素敏感性的决定因素。RBP 4胰岛素脱敏作用的机制尚不清楚。目的：本研究的目的是估计血清RBP 4浓度与胰岛素敏感性和氧化和非氧化葡萄糖代谢在瘦和肥胖women.Design和参与者之间的关系：研究组包括67名妇女与正常的葡萄糖耐量，27瘦和40超重或肥胖。用正常血糖高胰岛素钳夹法测定胰岛素敏感性。在基础状态和钳夹的最后30分钟期间，用间接量热法测量葡萄糖和脂质氧化。非氧化葡萄糖代谢计算胰岛素刺激的条件下减去葡萄糖氧化从总glucose metabolism.Results：有瘦和肥胖妇女之间的血清RBP 4浓度没有差异。在整个组中，血清RBP 4与胰岛素敏感性和非氧化性葡萄糖代谢呈负相关（两种情况下r =-0.36，P = 0.003），并且在瘦的亚组内，（r =-0.41，P = 0.034和r =-0.41，P = 0.031）和肥胖妇女（r =-0.41，P = 0.009和r =-0.40，P = 0.01）。这些关系独立于潜在的混杂因素。RBP 4水平与葡萄糖或脂质的氧化代谢无关。结论：我们的数据表明，血清RBP 4与胰岛素敏感性降低有关，主要是通过其与非氧化葡萄糖代谢。
Context: Retinol-binding protein (RBP) 4 is secreted by adipose tissue and is postulated to be a determinant of insulin sensitivity. The mechanisms of RBP4 insulin desensitizing action remain unclear.Objective: The aim of the present study was to estimate the relationships between serum RBP4 concentration with insulin sensitivity and oxidative and nonoxidative glucose metabolism in lean and obese women.Design and Participants: The study group consisted of 67 women with normal glucose tolerance, 27 lean and 40 overweight or obese. Insulin sensitivity was estimated with the euglycemic hyperinsulinemic clamp. Glucose and lipid oxidation was measured with indirect calorimetry in the basal state and during the last 30 min of the clamp. Nonoxidative glucose metabolism was calculated in insulin-stimulated conditions by subtracting glucose oxidation from total glucose metabolism.Results: There was no difference in serum RBP4 concentration between lean and obese women. Serum RBP4 was inversely related to insulin sensitivity and nonoxidative glucose metabolism in the entire group (r = -0.36, P = 0.003 in both cases) and within the subgroups of lean (r = -0.41, P = 0.034 and r = - 0.41, P = 0.031) and obese women (r = -0.41, P = 0.009 and r = -0.40, P = 0.01, respectively). These relationships were independent of potential confounding factors. RBP4 levels were not associated with oxidative metabolism of glucose or lipid.Conclusions: Our data indicate that serum RBP4 is related to decreased insulin sensitivity, mostly through its association with nonoxidative glucose metabolism.