A glycine-cleavage complex as part of the folate one-carbon metabolism of Plasmodium falciparum.
A glycine-cleavage complex as part of the folate one-carbon metabolism of Plasmodium falciparum.
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DOI：
10.1016/j.pt.2005.07.001
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发表时间：
2005-09
影响因子：
9.6
通讯作者：
Hyde, JE
中科院分区：
文献类型：
--
作者：
Salcedo, E;Sims, PFG;Hyde, JE
甘氨酸裂解复合体(GCV)和丝氨酸羟甲基转移酶代表了真核生物中活性叶酸辅助因子生物合成中的两个单碳转移系统。虽然对恶性疟原虫代谢的这一区域的了解还处于早期阶段，但我们讨论了GCV基因和转录产物在这种寄生虫中存在和表达的证据。还考虑了GCV的潜在作用及其与疟疾红细胞期的生命周期和发病机制的相关性。根据其表达谱，GCV似乎在配子体中特别活跃。GCV酶二氢硫酰胺脱氢酶有两种异构体，由两个不同的基因编码。最近已经证明这两个基因都有功能，其中一个被鉴定为丙酮酸脱氢酶复合体的一部分，该复合体仅存在于疟原虫物种的顶生质体中。另一个亚型可能形成了疟原虫GCV的一部分。GCV是这种寄生虫中第一个参与叶酸代谢的酶复合体，可以很确定地认为它位于线粒体中。
The glycine-cleavage complex (GCV) and serine hydroxymethyltransferase represent the two systems of one-carbon transfer that are employed in the biosynthesis of active folate cofactors in eukaryotes. Although the understanding of this area of metabolism in Plasmodium falciparum is still at an early stage, we discuss evidence that genes and transcription products of the GCV are present and expressed in this parasite. The potential role of the GCV and its relevance to the life cycle and pathogenesis of the malaria erythrocytic stages are also considered. According to its expression profile, the GCV seems to be particularly active in gametocytes. The GCV enzyme dihydrolipoamide dehydrogenase has two isoforms encoded by two different genes. It has been demonstrated recently that both genes are functional, with one of them identified as being part of a pyruvate dehydrogenase complex that is present exclusively in the apicoplast of Plasmodium species. The other isoform probably forms part of the Plasmodium GCV. The GCV is the first enzyme complex involved in folate metabolism in this parasite that can be assumed, with a good degree of certainty, to be located in the mitochondria.
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影响因子：
3.6
作者：
Foth, BJ;Stimmler, LM;McFadden, GI
通讯作者：
McFadden, GI
影响因子：
4.3
作者：
Conner, M;Krell, T;Lindsay, JG
通讯作者：
Lindsay, JG
影响因子：
15.9
作者：
HIRAGA, K;KOCHI, H;NYHAN, WL
通讯作者：
NYHAN, WL
影响因子：
2.7
作者：
Hyde, JE
通讯作者：
Hyde, JE
DOI：
10.1016/0169-4758(90)90148-w
发表时间：
1990-12-01
期刊：
PARASITOLOGY TODAY
影响因子：
--
作者：
KRUNGKRAI, J;WEBSTER, HK;YUTHAVONG, Y
通讯作者：
YUTHAVONG, Y