Replication and Expression Strategies of Viruses
Replication and Expression Strategies of Viruses
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DOI：
10.1016/b978-0-12-811257-1.00003-6
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发表时间：
2018-03-30
期刊：
影响因子：
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通讯作者：
Tennant P
中科院分区：
文献类型：
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作者：
Rampersad S;Tennant P
不管它们的基因构成如何，病毒基因组都是与活宿主细胞一起复制、表达和组装的。这些实体不经历分裂，而是通过预制组件的组装产生新的粒子。一些病毒通过改变细胞代谢来创造一个更有利于病毒基因表达的环境。在少数情况下，这些聪明的策略也有助于逃离宿主的防御反应。复制过程通常分为附着、进入、脱包衣、基因组复制和表达、组装、成熟以及最后从宿主细胞中退出或释放的阶段。在本章中，我们讨论基因组复制和表达，包括用于控制基因表达和确保病毒优先繁殖的多种策略。
Regardless of their genetic constitution, viral genomes are replicated, expressed, and assembled in association with living host cells. These entities do not undergo division, but rather generate new particles through the assembly of preformed components. Some viruses go further by modifying cellular metabolism to create a more favorable environment for viral gene expression. In a few instances, these clever strategies also facilitate escape from the host’s defense responses. The process of replication is typically divided into the phases of attachment, entry, uncoating, genome replication and expression, assembly, maturation, and finally, egress or release from the host cell. In this chapter, we address genome replication and expression, including the multiple strategies that serve to control gene expression and ensure preferential propagation of the virus.