Development of frequency tuning shaped by spatial cue reliability in the barn owl's auditory midbrain.
Development of frequency tuning shaped by spatial cue reliability in the barn owl's auditory midbrain.
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DOI：
10.7554/elife.84760
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发表时间：
2023-05-11
期刊：
影响因子：
7.7
通讯作者：
Peña JL
中科院分区：
文献类型：
--
作者：
Shadron K;Peña JL
感觉系统基于其在传递准确信息方面的可靠性而优先加强对刺激的反应。虽然以前的报告表明，大脑会根据可靠性的动态变化重新衡量线索，但大脑如何学习和维持对感官统计的神经反应，并期望随着时间的推移保持稳定，这是未知的。仓鸮的中脑有一个听觉空间图，神经元通过耳间时间差（ITD）计算水平声音的位置。中脑地图神经元的频率调谐与神经元的优选ITD的最可靠频率相关（Cazettes等人，2014年）。去除面部皱领导致从额部空间的高频率的可靠性的具体下降。为了直接测试ITD可靠性的永久性变化是否驱动频率调谐，记录了成年猫头鹰的中脑地图神经元，在发育过程中去除面部皱皮，以及未成年猫头鹰，在面部皱皮发育之前。在这两组中，额调谐神经元的频率低于正常成年猫头鹰，与ITD可靠性的变化一致。此外，青少年猫头鹰表现出更多的异质性频率调谐，这表明正常的发育过程完善调谐，以匹配ITD的可靠性。这些结果表明，因果关系的长期统计的空间线索的发展中脑频率调谐性能，实现概率编码的声音定位。
Sensory systems preferentially strengthen responses to stimuli based on their reliability at conveying accurate information. While previous reports demonstrate that the brain reweighs cues based on dynamic changes in reliability, how the brain may learn and maintain neural responses to sensory statistics expected to be stable over time is unknown. The barn owl’s midbrain features a map of auditory space where neurons compute horizontal sound location from the interaural time difference (ITD). Frequency tuning of midbrain map neurons correlates with the most reliable frequencies for the neurons’ preferred ITD (Cazettes et al., 2014). Removal of the facial ruff led to a specific decrease in the reliability of high frequencies from frontal space. To directly test whether permanent changes in ITD reliability drive frequency tuning, midbrain map neurons were recorded from adult owls, with the facial ruff removed during development, and juvenile owls, before facial ruff development. In both groups, frontally tuned neurons were tuned to frequencies lower than in normal adult owls, consistent with the change in ITD reliability. In addition, juvenile owls exhibited more heterogeneous frequency tuning, suggesting normal developmental processes refine tuning to match ITD reliability. These results indicate causality of long-term statistics of spatial cues in the development of midbrain frequency tuning properties, implementing probabilistic coding for sound localization.