A new polymorphic marker of the T-cell antigen receptor alpha chain genes in man.
A new polymorphic marker of the T-cell antigen receptor alpha chain genes in man.
复制标题
人类 T 细胞抗原受体 α 链基因的新多态性标记。
作者：
A. So;S. John;C. Bailey;M. Owen
对非重排T细胞抗原受体（Tcr）α链基因的限制性片段长度多态性进行了研究。Taq I探针，当用Tcr α链cDNA探针探测时，发现7.0，2.0和1.4 kb的多态性条带，由于C α基因和V基因簇周围的变异。家系研究证实了这些多态性带作为等位基因标记的分离。这些多态性为分析Tcr α链的遗传变异以及Tcr基因变异对免疫应答的影响提供了新的标记。
The restriction fragment length polymorphism of the unrearranged T-cell antigen receptor (Tcr) alpha chain gene was investigated. Taq I digests, when probed with a Tcr alpha chain cDNA probe, revealed polymorphic bands of 7.0, 2.0, and 1.4 kb, due to variations around the C alpha gene, and the V gene cluster. Family studies confirmed the segregation of these polymorphic bands as allelic markers. These polymorphisms provide a new marker for the analysis of genetic variation of the Tcr alpha chain, and the influence of variation of the Tcr genes on the immune response.