Nationwide clinical and epidemiological study of large-vessel vasculitis in Japan in 2017
Nationwide clinical and epidemiological study of large-vessel vasculitis in Japan in 2017
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DOI：
10.1093/mr/road019
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发表时间：
2023-02-04
影响因子：
2.2
通讯作者：
Harigai, Masayoshi
中科院分区：
文献类型：
--
作者：
Konda, Naoko;Sakai, Ryoko;Harigai, Masayoshi
目的对日本高须动脉炎（Takayasu arteritis， TAK）和巨细胞动脉炎（giant cell arteritis， GCA）患者进行全国范围的流行病学研究，分析其临床特征。方法第一次调查旨在估计2017年日本医疗机构治疗的TAK和GCA患者人数。第二次调查的目的是收集第一次调查中报告的患者的临床特征数据。结果在第一次调查中选定的3495所学校中，1960所（56.1%）回答了问题。临床诊断为TAK和GCA的患者数量估计分别为5320例（95%可信区间4810-5820）和3200例（95%可信区间2830-3570）。35%的TAK患者出现主动脉瓣反流，30.4%的GCA患者出现眼部相关合并症。颈总动脉和颈内动脉是TAK患者最常受累的部位（62.7%）。锁骨下动脉病变和胸腹主动脉病变分别占GCA患者的31%和42.6%。结论同时估计了TAK和GCA患者的数量，两种疾病的临床特征有显著差异。
Objective We conducted a nationwide epidemiological study to estimate the number of patients with Takayasu arteritis (TAK) and giant cell arteritis (GCA) in Japan and to describe the clinical characteristics of these patients. Methods The first survey was designed to estimate the number of patients with TAK and GCA who were treated at medical institutions in Japan in 2017. The second survey was designed to collect data on the clinical characteristics of the patients who were reported in the first survey. Results Of the 3495 institutions selected for the first survey, 1960 (56.1%) responded. The number of patients with clinically diagnosed TAK and GCA was estimated to be 5320 (95% confidence interval, 4810-5820) and 3200 (95% confidence interval, 2830-3570), respectively. Aortic regurgitation was reported in 35% of patients with TAK, and eye-related comorbidities were observed in 30.4% of patients with GCA. The common carotid and internal carotid arteries were the most frequently involved in patients with TAK (62.7%). Subclavian artery lesions and thoracic or abdominal aorta lesions were reported in 31% and 42.6% of patients with GCA, respectively. Conclusions The number of patients with TAK and GCA was estimated simultaneously, and significant differences in clinical characteristics were observed between the two diseases.