GENETIC-STRUCTURE OF NEISSERIA-GONORRHOEAE POPULATIONS - A NON-CLONAL PATHOGEN
GENETIC-STRUCTURE OF NEISSERIA-GONORRHOEAE POPULATIONS - A NON-CLONAL PATHOGEN
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DOI：
10.1099/00221287-139-11-2603
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发表时间：
1993-11-01
期刊：
影响因子：
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通讯作者：
STEVENS, E
中科院分区：
文献类型：
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作者：
OROURKE, M;STEVENS, E
通过二分裂的繁殖在没有高重组率的情况下在细菌群体中产生克隆遗传结构。淋病奈瑟菌自然群体中的重组程度是通过对全世界227个分离株中编码9个酶位点的结构基因的遗传学上可证实的等位基因变异进行分析来确定的。没有显着的连锁不平衡是显而易见的人口，表明重组必须是频繁的，相对于二分分裂。N.淋病与来自早期研究的枯草芽孢杆菌进行了比较。连锁不平衡在N.淋病人群比本地人群中的B。枯草，其中只有适度的克隆结构是明显的。因此，N.淋病与迄今所研究的病原体不同，具有非克隆种群结构。正如在自由重组人群中所预期的那样，电泳基因型与血清型或营养型之间没有相关性。
Reproduction by binary fission generates a clonal genetic structure in bacterial populations in the absence of a high rate of recombination. The extent of recombination in natural populations of Neisseria gonorrhoeae was determined from an analysis of electrophoretically demonstrable allelic variation at structural genes encoding nine enzyme loci in 227 worldwide isolates. No significant linkage disequilibrium was evident in the population, indicating that recombination must be frequent, relative to binary fission. The genetic structure of N. gonorrhoeae was compared with that of Bacillus subtilis from an earlier study. Linkage disequilibrium was less extreme in the N. gonorrhoeae population than in the local population of B. subtilis, in which only modest clonal structure was evident. Thus, N. gonorrhoeae, unlike pathogens so far examined, has a non-clonal population structure. As expected in a freely recombining population, no correlation was found between electrophoretic genotype and serovar or auxotype.