Diagnostic and prognostic value of fibrin stabilising factor in Schönlein-Henoch syndrome.
Diagnostic and prognostic value of fibrin stabilising factor in Schönlein-Henoch syndrome.
复制标题
纤维蛋白稳定因子对 Schönlein-Henoch 综合征的诊断和预后价值。
DOI：
10.1136/adc.58.1.12
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发表时间：
1983
影响因子：
5.2
通讯作者：
Bezou Mj
中科院分区：
文献类型：
--
作者：
B. Dalens;P. Travade;A. Labbe;Bezou Mj
对196例儿童循环血液中的纤维蛋白稳定因子（FSF）进行了研究。这196名儿童分为三组：131名对照组（A组），20名患有对FSF检测有潜在影响的疾病的儿童（B组）和45名Schönlein-Henoch综合征儿童（C组）。A组和B组的测定结果正常，但C组的结果在血管炎发病时明显较低。17名患有Schönlein-Henoch综合征的儿童出现了并发症，其中7人病情严重。FSF水平的降低与这些并发症的严重程度相关，而FSF的增加与康复有关。FSF活性的测定似乎有助于Schönlein-Henoch血管炎的诊断，也有助于监测疾病的进程和评估并发症的风险。
Fibrin stabilising factor (FSF) was studied in the circulating blood of 196 children. These 196 children comprised three groups: 131 controls (group A), 20 children with diseases of potential repercussion on FSF determination (group B), and 45 children with Schönlein-Henoch syndrome (group C). Determinations from groups A and B produced normal values, but results from group C were significantly lower at the onset of the vasculitis. Seventeen children with Schönlein-Henoch syndrome have had complications, in 7 of whom these were severe. The decrease in FSF levels was correlated with the severity of such complications, and an increase in FSF was associated with recovery. Determination of FSF activity appears to help in the diagnosis of Schönlein-Henoch vasculitis, as well as helping to monitor the course of the disease and assessing the risks of complications.