Faster thalamocortical processing for dark than light visual targets.
Faster thalamocortical processing for dark than light visual targets.
复制标题
丘脑皮质对暗视觉目标的处理速度比对亮视觉目标的处理速度更快。
DOI：
10.1523/jneurosci.2456-11.2011
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发表时间：
2011-11-30
期刊：
影响因子：
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通讯作者：
Alonso JM
中科院分区：
文献类型：
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作者：
Jin J;Wang Y;Lashgari R;Swadlow HA;Alonso JM
On和Off视觉通路起源于视网膜的感光细胞和双极细胞之间的突触。非双极细胞的长度比双极细胞短，使用受体的动力学比双极细胞快，因此处理信息的速度更快。在这里，我们证明了这种时间优势是通过丘脑皮质处理来保持的，视觉反应在视觉反应之前大约3-6毫秒到达皮质。来自代表视觉中心(X和Y)的大量猫丘脑神经元以及与同一皮质定向柱连接的亚群的记录可以显示出更快的脱离视觉反应。当视觉反应达到峰值时，Off的时间优势减弱，而Off的脉冲反应积分大于神经元。考虑到来自关闭和打开通道的刺激偏好，我们的结果表明，在丘脑皮质通路中，黑暗的处理速度快于光。
ON and OFF visual pathways originate in the retina at the synapse between photoreceptor and bipolar cells. OFF bipolar cells are shorter in length and use receptors with faster kinetics than ON bipolar cells and, therefore, process information faster. Here, we demonstrate that this temporal advantage is maintained through thalamocortical processing, with OFF visual responses reaching cortex ~ 3–6 milliseconds before ON visual responses. Faster OFF visual responses could be demonstrated in recordings from large populations of cat thalamic neurons representing the center of vision (both X and Y) and from subpopulations making connection with the same cortical orientation column. While the OFF temporal advantage diminished as visual responses reached their peak, the integral of the impulse response was greater in OFF than ON neurons. Given the stimulus preferences from OFF and ON channels, our results indicate that darks are processed faster than lights in the thalamocortical pathway.