Cullin 3 as a novel target in diverse pathologies.
Cullin 3 as a novel target in diverse pathologies.
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DOI：
10.1016/j.redox.2013.07.003
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发表时间：
2013-07-16
期刊：
影响因子：
11.4
通讯作者：
Pedraza-Chaverri, Jose
中科院分区：
文献类型：
--
作者：
Cristina Anderica-Romero, Ana;Gabriela Gonzalez-Herrera, Irma;Santamaria, Abel;Pedraza-Chaverri, Jose
最近的证据表明，被称为泛素-蛋白酶体系统(UPS)的细胞蛋白质故障处理系统在包括癌症和神经退行性疾病在内的疾病的发展中发挥着重要作用。越来越多的证据表明，作为UPS的重要组成部分，E3泛素连接酶及其底物参与了细胞周期进程、基因转录、信号转导、DNA复制等的调控，从而导致了UPS的失控增殖、基因组不稳定和癌症。E3连接酶通过选择性降解特定底物，调节不同的生物过程。库林斯蛋白是一类底物专一性的蛋白质家族，它与作为支架蛋白的E3连接酶多聚体复合体结合。到目前为止，已经确定了cullin蛋白家族的七个成员。有趣的是，由几个小组产生的数据表明，cullin 3(CUL3)已经开始作为一种与多种疾病的病因有关的蛋白质出现。在这篇论文中，我们审查了关于CUL3生物学的基础研究的最新进展，以及它如何有助于指导针对这一目标的药物发现努力。蛋白质降解最重要的系统是泛素-蛋白酶体系统。泛素化的特定底物是高度特异的，这种活性可以由E3泛素连接酶提供。基于库林斯的E3泛素连接酶是研究较多的泛素连接酶类型。由于与多种BTB-蛋白相互作用，cullin 3复合体已成为靶标。CULLIN 3可能是一个具有很高治疗潜力的分子。
Recent evidence suggests that the malfunctioning disposal system of cell protein called ubiquitin–proteasome system (UPS) plays an important role in the development of disorders, including cancer and neurodegenerative diseases. Accumulating evidence suggests that the abnormal regulation of the E3 ubiquitin ligases, essential components of the UPS, contributes to uncontrolled proliferation, genomic instability and cancer, since these ligases and their substrates are involved in the regulation of cell cycle progression, gene transcription, signal transduction, DNA replication and others. Through selective degradation of specific substrates, E3 ligases regulate different biological processes. Cullins are a family of proteins that confer substrate specificity to multimeric complex of E3 ligases acting as scaffold proteins. So far, seven members of the cullin family of proteins have been identified. Interestingly, the data generated by several groups indicate that cullin 3 (Cul3) has begun to emerge as a protein involved in the etiopathology of multiple diseases. In this paper we examine the latest advances in basic research on the biology of Cul3 and how it could help to direct drug discovery efforts on this target. The most important system for protein degradation is the ubiquitin–proteasome system. The specific substrate for ubiquitination is highly specific and this activity can be provided by the E3 ubiquitin ligases. The E3 ubiquitin ligases based on cullins are the type of ubiquitin ligases more studied. The cullin 3 complex has emerged as a target due to its interaction with a wide range of BTB-proteins. Cullin 3 could be a molecule with a high therapeutic potential.
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影响因子：
10.5
作者：
Itoh, K;Wakabayashi, N;Yamamoto, M
通讯作者：
Yamamoto, M
影响因子：
4.7
作者：
Dequen, Florence;Bomont, Pascale;Julien, Jean-Pierre
通讯作者：
Julien, Jean-Pierre
DOI：
10.1093/brain/awq108
发表时间：
2010-07
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Cirak S;von Deimling F;Sachdev S;Errington WJ;Herrmann R;Bönnemann C;Brockmann K;Hinderlich S;Lindner TH;Steinbrecher A;Hoffmann K;Privé GG;Hannink M;Nürnberg P;Voit T
通讯作者：
Voit T
NRF2：氧化应激中的INRF2（KEAP1）信号传导。
影响因子：
7.4
作者：
Kaspar, James W.;Niture, Suryakant K.;Jaiswal, Anil K.
通讯作者：
Jaiswal, Anil K.
影响因子：
6.2
作者：
Edelmann MJ;Nicholson B;Kessler BM
通讯作者：
Kessler BM