Parkinson's disease, depression, and ECT: a review and case study.
Parkinson's disease, depression, and ECT: a review and case study.
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帕金森病、抑郁症和 ECT：回顾和案例研究。
DOI：
10.1176/ajp.134.2.191
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
G. Asnis
中科院分区：
文献类型：
--
作者：
G. Asnis
作者回顾了帕金森病和抑郁症之间的联系，并提出证据支持抑郁症可能不仅是反应性的，而且与疾病有关的生化假设。一名帕金森症精神抑郁患者对ECT治疗反应积极，表现为抑郁评定量表、两个锥体外系评定量表和笔迹样本的改善。对帕金森病症状的有益作用发生在抑郁症改善之前，这表明ECT具有特异性抗帕金森病作用。基于抑郁症的生物化学理论，对这一观察结果的可能解释进行了讨论。
The author reviews the association between Parkinson's disease and depression and presents evidence to support the hypothesis that depression may be not only reactive but biochemically related to the disease. A psychotically depressed patient with parkinsonism responded positively to ECT as shown by improvement on a depression rating scale, two extrapyramidal rating scales, and handwriting samples. The beneficial effect on parkinsonian signs occurred before the improvement in depression, which suggests that ECT has a specific antiparkinsonian effect. Possible explanations for this observation based on biochemical theories of depression are discussed.