Seven interferon gamma response genes serve as a prognostic risk signature that correlates with immune infiltration in lung adenocarcinoma.
Seven interferon gamma response genes serve as a prognostic risk signature that correlates with immune infiltration in lung adenocarcinoma.
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七个干扰素γ反应基因可作为与肺腺癌免疫浸润相关的预后风险特征
DOI：
10.18632/aging.202831
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发表时间：
2021-04-04
期刊：
影响因子：
--
通讯作者：
Huang X
中科院分区：
文献类型：
--
作者：
Yao B;Wang L;Wang H;Bao J;Li Q;Yu F;Zhu W;Zhang L;Li W;Gu Z;Fei K;Zhang P;Zhang F;Huang X
干扰素γ（IFN-γ）在调节肺腺癌（LUAD）发育过程中在调节肿瘤微环境中起着复杂的作用。 GA队列，显示出显着差异在这些基因的表达中，鉴定出生存率。高风险群体恢复细胞周期和DNA复制的属性，以及高肿瘤的免疫力，此外，风险评分与免疫元素的表达有负相关，但是我们的发现与DNA损伤修复基因相关，我们的发现可能是七个基因的预测者。
Interferon-gamma (IFN-γ) plays a complex role in modulating tumor microenvironment during lung adenocarcinoma (LUAD) development. In order to define the role of IFN-γ response genes in LUAD progression, we characterized the gene expression, mutation profile, protein-protein interaction of 24 IFN-γ response genes, which exhibited significant hazard ratio in overall survival. Two subgroups of LUAD from the TCGA cohort, which showed significant difference in the survival rate, were identified based on the expression of these genes. Furthermore, LASSO penalized cox regression model was used to derive a risk signature comprising seven IFN-γ response genes, including CD74, CSF2RB, PTPN6, MT2A, NMI, LATS2, and PFKP, which can serve as an independent prognostic predictor of LUAD. The risk signature was validated in an independent LUAD cohort. The high risk group is enriched with genes regulating cell cycle and DNA replication, as well as a high level of pro-tumor immune cells. In addition, the risk score is negatively correlated with the expression of immune metagenes, but positively correlated with DNA damage repair genes. Our findings reveal that seven-gene risk signature can be a valuable prognostic predictor for LUAD, and they are crucial participants in tumor microenvironment of LUAD.
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DOI：
10.1038/nrc3239
发表时间：
2012-03-22
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Pardoll DM
通讯作者：
Pardoll DM
影响因子：
3.5
作者：
Lee, SJ;Jang, BC;Choi, IH
通讯作者：
Choi, IH
影响因子：
8.8
作者：
St-Denis, Nicole;Gupta, Gagan D.;Gingras, Anne-Claude
通讯作者：
Gingras, Anne-Claude
影响因子：
6.2
作者：
Duque, Gustavo;Huang, Dao Chao;Kremer, Richard
通讯作者：
Kremer, Richard
影响因子：
8.8
作者：
Abiko, K.;Matsumura, N.;Hamanishi, J.;Horikawa, N.;Murakami, R.;Yamaguchi, K.;Yoshioka, Y.;Baba, T.;Konishi, I.;Mandai, M.
通讯作者：
Mandai, M.