Heritability of changes in bone size and bone mass with age in premenopausal white sisters
Heritability of changes in bone size and bone mass with age in premenopausal white sisters
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DOI：
10.1359/jbmr.060412
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发表时间：
2006-07-01
影响因子：
6.2
通讯作者：
Peacock, M
中科院分区：
文献类型：
--
作者：
Hui, SL;Koller, DL;Peacock, M
简介：骨量和结构是高度遗传的。然而，遗传对成年人骨量和结构的年龄相关变化的影响却少得多studyed.Materials和方法：对来自178个家庭的388名健康白色绝经前姐妹篇进行DXA测量。股骨颈面积、BMC和BMD以及体重的变化率是根据平均间隔5.7年的两次测量结果计算的。混合模型用于测试骨骼变化是否与年龄或体重变化相关。方差分量模型用于估计变化率的遗传力。结果：股骨颈面积随年龄增长而增大，而骨密度随年龄增长而减小。所有股骨颈的变化率与体重变化呈正相关，但股骨颈的变化率不随年龄变化。调整体重变化后，股骨颈BMC变化为负值。股骨颈BMC、BMD和经体重调整后的面积的变化检测到显著的遗传力（0.29-0.36）。校正DXA测量误差的估计率增加了遗传力估计值（从0.29-0.36范围到0.37-0.64范围）。结论：绝经前白色妇女的股骨颈面积，BMC和BMD的变化率是可遗传的。
Introduction: Bone mass and structure are highly heritable. However, genetic effects on age-related changes in bone mass and structure in adults have been much less studied.Materials and Methods: DXA measurements were made on 388 healthy white premenopausal sisters from 178 families. Rates of change in femoral neck area, BMC, and BMD, as well as body weight, were calculated from two measurements made an average of 5.7 years apart. Mixed models were used to test whether bone changes were related to age or weight change. Variance components models were used to estimate the heritability of the rates of change. A method was proposed to correct for the underestimation of heritabilities caused by measurement errors of the rates of change.Results: Femoral neck area increased with age, whereas BMD decreased. All of the rates of change at the femoral neck were positively correlated with weight change, but the rates of femoral neck changes did not vary with age. Adjusted for weight change, change in femoral neck BMC became negative. Significant heritabilities (0.29-0.36) were detected for changes in femoral neck BMC, BMD, and area adjusted for weight changes. Correction for DXA measurement error in the rate estimates increased the heritability estimates (from 0.29-0.36 range to 0.37-0.64 range).Conclusions: Rates of change are heritable for femoral neck area, BMC, and BMD in premenopausal white women.