MRI Spectrum of Japanese Encephalitis in Northeast India: A Cross-Sectional Study.
MRI Spectrum of Japanese Encephalitis in Northeast India: A Cross-Sectional Study.
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DOI：
10.1055/s-0041-1722820
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发表时间：
2021-04
影响因子：
1.4
通讯作者：
Chuunthang D
中科院分区：
文献类型：
--
作者：
Phukan P;Sarma K;Sharma BK;Boruah DK;Gogoi BB;Chuunthang D
目的乙脑是一种由节肢动物传播的黄病毒感染，病死率和致残率均较高。 乙型脑炎是一种由节肢动物传播的黄病毒感染。本研究旨在评估乙脑的常规磁共振成像(MRI)表现，并找出儿童乙脑与成人乙脑之间的差异。材料和方法 本研究对2016年4月至2019年10月在三级医院就诊的54例乙脑患者进行了回顾性研究。进行相关的神经学检查、脑脊液分析及脑部MRI扫描。结果纳入 的乙脑患者54例(男31例，女23例)，其中儿童32例，成人22例。第一组(n=16)有脑炎症状，持续时间小于15d，第二组(n=38)症状持续时间超过15d。第1组的表观扩散系数为0.563±0.109(标准差)×10-3mm2/s，第2组的表观扩散系数为1.095±0.206(SD)×10-3mm2/s。儿童乙脑平均ADC值为0.907±0.336(SD)×10-3mm2/s，成人乙脑平均ADC值为0.982±0.253(SD)×10-3mm2/s。结论 主要表现为双侧丘脑和黑质异常信号改变。弥散加权成像和ADC映射有助于评估JE的分期。在儿童乙脑和成人乙脑之间，各种常规MRI表现没有统计学意义。
Objective Japanese encephalitis (JE) is an arthropod-borne flavivirus infection having high mortality and morbidity. This study was performed to evaluate the conventional magnetic resonance imaging (MRI) findings in JE and to find out any difference between pediatric and adult JE. Materials and Methods This retrospective study was performed on serologically positive 54 JE patients presented to a tertiary care hospital with acute encephalitic symptoms between April 2016 and October 2019. Relevant neurological examination, cerebrospinal fluid analysis, and MRI scan of the brain were performed. Results Fifty-four JE patients ( n = 31 males and n = 23 females) having 32 pediatric and 22 adult JE were included in the study sample. Group 1 JE ( n = 16) patients had encephalitic symptoms with duration less than 15 days up to the day of MRI scan and group 2 JE ( n = 38) had symptoms more than 15 days. Group 1 JE had mean apparent diffusion coefficient (ADC) value of 0.563 ± 0.109 (standard deviation [SD]) × 10 –3 mm 2 /sec and group 2 JE had 1.095 ± 0.206 (SD) × 10 –3 mm 2 /sec. The mean ADC value of pediatric JE was 0.907 ± 0.336 (SD) × 10 –3 mm 2 /sec and adult JE was 0.982 ± 0.253 (SD) × 10 –3 mm 2 /sec. Conclusion The majority of the JE patient shows abnormal signal alterations in bilateral thalami and substantia nigra. Diffusion-weighted imaging with ADC mapping helps in evaluating the stage of the JE. No statistical significance of the various conventional MRI findings was found between the pediatric JE and adult JE.