PHOTOSENSITISING ACTIVITY OF PHTHALOCYANINE DYES SCREENED AGAINST TISSUE CULTURE CELLS
PHOTOSENSITISING ACTIVITY OF PHTHALOCYANINE DYES SCREENED AGAINST TISSUE CULTURE CELLS
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针对组织培养细胞筛选酞菁染料的光敏活性
DOI：
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发表时间：
1987
影响因子：
3.3
通讯作者：
I. Hart
中科院分区：
文献类型：
--
作者：
W. Chan;J. Marshall;R. Svensen;D. Phillips;I. Hart
抽象。筛选了一系列酞菁（Pc）染料的光敏化小鼠胚胎成纤维细胞或纤维肉瘤细胞的能力。在染料存在下培养细胞24小时。然后用室内光或红光照射，再培养72小时。以这种方式筛选了11种水不溶性Pc（包括游离碱Pc）和6种水溶性磺化衍生物。游离碱（H2）、铜（Cu）、铜二。三，四磺化（CuS2，CuS3。CuS4）、氟铬（FCr）、铁（Fe）、钴（Co）、四磺化钯（PdS4）。在这些试验中，镍（Ni）和四磺化镍（NiS4）Pc染料在室内光或红光暴露条件下均无细胞毒性活性。镁（Mg），锌（Zn）和锆（Zr）Pc染料是高毒性的细胞，产生0%的生存在72小时，暴露于两种光源。氯铝（C1Al）。磺化氯铝（C1A1S）和二氯锡（Cl2Sn）Pc染料表现出不同的光毒性，在红光照射后产生总细胞死亡，但在暴露于室内光后没有或几乎没有细胞毒性作用，提高了这些染料可能被证明可用于癌症的光动力疗法的可能性。
Abstract. A series of phthalocyanine (Pc) dyes were screened for their ability to photosensitise murine embryonic fibroblasts or fibrosarcoma cells. Cells were cultured in the presence of the dyes for 24 h. following which they were irradiated with either room light or red light and cultured for a further 72‐h period. Eleven water‐insoluble Pc (including a free‐base Pc) and 6 water‐soluble sulfonated derivatives were screened in this fashion. Free base (H2), copper (Cu), copper di‐. tri‐, tetra‐sulfonated (CuS2, CuS3. CuS4), fiuoro chromium (FCr), iron (Fe), cobalt (Co), palladium tetra‐sulfonated (PdS4). nickel (Ni) and nickel tetra‐sulfonated (NiS4)Pc dyes had no cytotoxic activity in these assays under conditions of either room‐light or red‐light exposure. Magnesium (Mg), zinc (Zn) and zirconium (Zr) Pc dyes were highly toxic to cells, producing 0% survival at 72 h, following exposure to both light sources. In contrast, chloro aluminum (C1AI). chloro aluminum sulfonated (C1A1S) and dichloro tin (Cl2Sn) Pc dyes exhibited differential phototoxicity, producing total cell death following red‐light irradiation but no or little cytotoxic effect after exposure to room light, raising the possibility that these dyes might prove useful for photo‐dynamic therapy of cancer.
四磺酞菁锌作为生物分子的光动力敏化剂。
DOI：
10.1080/09553008614550421
发表时间：
1986
期刊：
International journal of radiation biology and related studies in physics, chemistry, and medicine
影响因子：
--
作者：
Spikes,JD;Bommer,JC
通讯作者：
Bommer,JC