Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6
Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6
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DOI：
10.1074/jbc.273.3.1741
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发表时间：
1998-01-16
影响因子：
4.8
通讯作者：
Davis, RJ
中科院分区：
文献类型：
--
作者：
Enslen, H;Raingeaud, J;Davis, RJ
细胞对促炎细胞因子处理或环境应激的反应部分是由丝裂原活化蛋白（MAP）激酶的p38家族介导的。我们报道了一种新型的p38 MAP激酶异构体p38β2的分子克隆。这种p38 MAP激酶与p38α一样，可被吡啶基咪唑类药物SB203580抑制。p38 MAP激酶激酶MKK6被确定为p38α、p38β2和p38γ MAP激酶异构体的共同激活剂，而MKK3仅激活p38α和p38γ MAP激酶异构体。因此，MKK3和MKK6信号转导途径与不同但有重叠的p38 MAP激酶组相偶联。
The cellular response to treatment with proinflammatory cytokines or exposure to environmental stress is mediated, in part, by the p38 group of mitogen-activated protein (MAP) kinases. We report the molecular cloning of a novel isoform of p38 MAP kinase, p38 beta 2. This p38 MAP kinase, like p38 alpha, is inhibited by the pyridinyl imidazole drug SB203580. The p38 MAP kinase kinase MKK6 is identified as a common activator of p38 alpha, p38 beta 2, and p38 gamma MAP kinase isoforms, while MKK3 ac- tivates only p38 alpha and p38 gamma MAP kinase isoforms. The MKK3 and MKK6 signal transduction pathways are therefore coupled to distinct, but overlapping, groups of p38 MAP kinases.