Levels of mint and wintergreen flavorants: Smokeless tobacco products vs. confectionery products
Levels of mint and wintergreen flavorants: Smokeless tobacco products vs. confectionery products
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DOI：
10.1016/j.fct.2009.12.015
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发表时间：
2010-02-01
影响因子：
4.3
通讯作者：
Pankow, J. F.
中科院分区：
文献类型：
--
作者：
Chen, C.;Isabelle, L. M.;Pankow, J. F.
对无烟烟草（SLT）中10个“薄荷”相关子品牌和8个“冬青”子品牌的尼古丁和香料化合物含量进行了测定，并对“薄荷”无烟烟草（SLT）中“薄荷”相关和“冬青”糖果产品进行了分析。“森林狼薄荷袋”的薄荷醇含量最高（5.3 mg/g）；五种薄荷含量最高的SLT产品的平均含量为4.3毫克/克，五种薄荷含量最高的糖果产品的平均含量为3.5毫克/克。据报道，硬糖的平均最高使用量为2.1毫克/克（Burdock, 2009）。在“冬青”SLT中，“Hawken wintergreen”被发现含有最高的水杨酸甲酯（MS）含量（29.7毫克/克）。5种最高SLT MS含量的平均值为23.8毫克/克。即. .比MS含量最高的糖果产品（LifeSavers Wint O Green Sugar Free, 4.6 mg/g）的含量高5倍。据报道，硬糖的平均最大使用量为20毫克/克（Burdock, 2009）。假设SLT为23.8 mg/g MS。按15克/天使用SLT， MS 100%身体吸收，体重为60公斤，平均每日摄入量为6.0毫克/公斤-天，即粮农组织/世卫组织联合委员会为该化合物确定的可接受日摄入量（ADI） 0.5毫克/公斤-天的12倍。2009爱思唯尔有限公司版权所有
Nicotine and flavorant compound levels were measured in 10 "mint"-related sub-brands and 8 "wintergreen" sub-brands of smokeless tobacco (SLT) Also analyzed were "mint"-related and "wintergreen" confectionery products Of the "mint" SLT. "Timberwolf Packs Mint Pouches" contained the highest menthol level (5.3 mg/g); the average for the five most-highly mentholated SLT products was 4.3 mg/g The average for the most five most-highly mentholated confectionery products was 3.5 mg/g. For hard candy, a reported average of maximum use levels is 2.1 mg/g (Burdock, 2009) Of the "wintergreen" SLT, "Hawken Wintergreen" was found to contain the highest methyl salicylate (MS) level (29 7 mg/g) The average of the five highest SLT MS levels was 23.8 mg/g. i.e.. 5 x higher than the level found in the confectionery product with the highest MS level (LifeSavers Wint O Green Sugar Free, 4.6 mg/g). For hard candy, a reported average of maximum use levels is 20 mg/g (Burdock, 2009). Assuming 23.8 mg/g MS in SLT. SLT use at 15 g/day, 100% bodily absorption of the MS, and 60 kg body weight, the average daily intake would be 6.0 mg/kg-day, i.e., 12x the acceptable daily intake (ADI) of 0.5 mg/kg-day established for this Compound by a joint FAO/WHO committee. (C) 2009 Elsevier Ltd. All rights reserved