Crystallization of human c-H-ras oncogene products.
Crystallization of human c-H-ras oncogene products.
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人类 c-H-ras 癌基因产物的结晶。
DOI：
10.1016/0022-2836(88)90345-2
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发表时间：
1988
影响因子：
5.6
通讯作者：
Nishimura,S
中科院分区：
文献类型：
--
作者：
Jancarik,J;deVos,A;Kim,SH;Miura,K;Ohtsuka,E;Noguchi,S;Nishimura,S
有令人信服的证据表明，癌症的发展是一组选定的细胞基因中某些成员的遗传变化（可能是多个）的结果。从各种肿瘤而不是正常组织中分离的DNA具有恶性转化非致瘤细胞的能力。许多负责这种转化的癌基因已经从转化的细胞系以及由病毒、化学品或辐射自发诱导的动物和人类肿瘤中分离出来。用DNA转染法从人肿瘤细胞中分离到的最常见的转化基因是ras基因家族（c-H-ras、c-K-ras和N-ras）。我们报告了几种人c-H-ras癌基因蛋白的结晶。
There is compelling evidence that cancer develops as a consequence of genetic changes (probably multiple) in some members of a selected set of cellular genes. DNA isolated from a variety of tumors, but not normal tissues, possesses the ability to malignantly transform non-tumorigenic cells. Many oncogenes responsible for such transformation have been isolated from transformed cell lines and animal and human tumors induced spontaneously, by virus, by chemical, or by radiation. The most commonly found transforming genes isolated from human tumor cells by DNA transfection assay are therasgene family (c-H-ras, c-K-rasand N-ras). We report crystallization of several human c-H-rasoncogene proteins.