Surveillance of illness associated with pandemic (H1N1) 2009 virus infection among adults using a global clinical site network approach: The INSIGHT FLU 002 and FLU 003 studies
Surveillance of illness associated with pandemic (H1N1) 2009 virus infection among adults using a global clinical site network approach: The INSIGHT FLU 002 and FLU 003 studies
复制标题
DOI：
10.1016/j.vaccine.2011.04.105
复制
发表时间：
2011-07-22
期刊：
影响因子：
5.5
通讯作者：
Dwyer, Dominic E.
中科院分区：
文献类型：
--
作者：
Dwyer, Dominic E.
2009年，新型大流行性甲型流感（H1H1）病毒在全球迅速传播。由于缺乏关于2009年H1N1流感大流行病毒感染临床结果预测因子的前瞻性国际流行病学数据，促使INSIGHT网络（一个由社区和医院调查员组成的国际网络）开展了两项全球临床观察性研究，以描述2009年H1N1流感大流行病毒的活动。这两项研究的目的是估计因实验室确认的2009年H1N1流感大流行病毒感染而患病的成年患者出现临床显著结果的百分比，并研究与这些结果相关的因素。研究于2009年10月开始，并将持续到2011年8月：截至2010年底，澳大利亚（12个）、欧洲（37个）和北美（13个）14个国家的62个研究点共招募了1365名成年患者，其中1049名患者参加了FLU 002门诊研究，316名患者参加了FLU 003住院研究。这些“正在进行”的INSIGHT流感观察研究可以作为一种模式，在未来的国际疾病暴发中获取流行病学、临床和实验室信息。(C) 2011 Elsevier Ltd.版权所有。
The novel pandemic influenza A (H1H1) 2009 virus spread rapidly around the world in 2009. The paucity of prospective international epidemiologic data on predictors of clinical outcomes with pandemic (H1N1) 2009 virus infection stimulated the INSIGHT network, an international network of community and hospital-based investigators, to commence two worldwide clinical observational studies to describe pandemic (H1N1) 2009 virus activity.The purpose of these two studies was to estimate the percent of adult patients with illness due to laboratory-confirmed pandemic (H1N1) 2009 virus infection that experience clinically significant outcomes and to study factors related to these outcomes.Enrollment commenced in October 2009 and will continue until August 2011: as of the end of 2010, 62 sites in 14 countries in Australasia (12 sites), Europe (37) and North America (13) have enrolled 1365 adult patients, with 1049 enrollments into the FLU 002 outpatient study and 316 into the FLU 003 hospitalization study.These 'in progress' INSIGHT influenza observational studies may act as a model for obtaining epidemiological, clinical and laboratory information in future international disease outbreaks. (C) 2011 Elsevier Ltd. All rights reserved.