Regulation of post-Golgi traffic of G protein-coupled receptors.
Regulation of post-Golgi traffic of G protein-coupled receptors.
复制标题
DOI：
10.1007/978-94-007-4765-4_5
复制
发表时间：
2012
影响因子：
--
通讯作者：
Wu, Guangyu
中科院分区：
文献类型：
--
作者：
Wu, Guangyu
新合成的G蛋白偶联受体(GPCRs)从内质网到细胞表面的顺行运输是控制细胞表面功能性受体数量和受体启动的信号强度的关键检查点。与广泛研究的、被广泛了解的内吞和循环途径相比，受体的细胞表面靶向的分子机制仍然不清楚。在这一章中，我将通过重点介绍特定的基序或序列来讨论目前在理解GPCRs高尔基体后运输方面的进展，这些基序或序列可能起到调节高尔基体输出和随后向GPCRs质膜运输的分选信号的作用。
Anterograde trafficking of newly synthesized G protein-coupled receptors (GPCRs) from the endoplasmic reticulum to the cell surface represents a crucial checkpoint in controlling the amount of the functional receptors at the cell surface and the strength of signaling initiated by the receptors. In contrast to the extensively studied, well-understood endocytic and recycling pathways, the molecular mechanisms underlying the cell-surface targeting of the receptors remain poorly defined. In this chapter, I will discuss current advances in understanding post-Golgi transport of GPCRs by focusing on specific motifs or sequences that may function as sorting signals regulating export from the Golgi and subsequent transport to the plasma membrane of GPCRs.