Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States - Data from the Third National Health and Nutrition Examination Survey
Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States - Data from the Third National Health and Nutrition Examination Survey
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DOI：
10.1001/archinte.167.11.1159
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发表时间：
2007-06-11
影响因子：
--
通讯作者：
Norris, Keith
中科院分区：
文献类型：
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作者：
Martins, David;Wolf, Myles;Norris, Keith
工作背景：一些流行病学和临床研究的结果表明，有一个过高的风险高血压和糖尿病的人与次优摄入的维生素D。方法：我们研究了25-羟基维生素D（25[ OH] D）和选择心血管疾病的危险因素在美国成年人的血清水平之间的关联。第三次全国健康和营养检查调查的数据进行了二次分析，这是一项由国家卫生统计中心在1988年1月1日至1994年12月31日期间进行的全国概率调查，对60岁及以上的人、非西班牙裔黑人和墨西哥裔美国人进行了过抽样。在第三次全国健康和营养检查调查中，有7186名男性和7902名女性20岁及以上的成年人提供了数据。总体样本中的平均25（OH）D水平为30 ng/mL（75 nmol/L）。女性、老年人（>= 60岁）、少数民族和肥胖、高血压和糖尿病患者的25（OH）D水平较低。高血压校正患病率（比值比[ OR]，1.30），糖尿病（OR，1.98），肥胖（OR，2.29），高血清甘油三酯水平血清25（OH）D水平第一四分位数显著高于第一四分位数（OR，1.47结论：血清25（OH）D水平与美国成年人重要的心血管疾病危险因素相关。有必要进行前瞻性研究，以评估补充胆钙化醇（维生素D）对心血管疾病风险因素的直接益处。
Background: Results of several epidemiologic and clinical studies have suggested that there is an excess risk of hypertension and diabetes mellitus in persons with suboptimal intake of vitamin D.Methods: We examined the association between serum levels of 25-hydroxyvitamin D ( 25[ OH] D) and select cardiovascular disease risk factors in US adults. A secondary analysis was performed with data from the Third National Health and Nutrition Examination Survey, a national probability survey conducted by the National Center for Health Statistics between January 1, 1988, and December 31, 1994, with oversampling of persons 60 years and older, non-Hispanic black individuals, and Mexican American individuals.Results: There were 7186 male and 7902 female adults 20 years and older with available data in the Third National Health and Nutrition Examination Survey. The mean 25( OH) D level in the overall sample was 30 ng/mL ( 75 nmol/L). The 25( OH) D levels were lower in women, elderly persons ( >= 60 years), racial/ethnic minorities, and participants with obesity, hypertension, and diabetes mellitus. The adjusted prevalence of hypertension ( odds ratio [ OR], 1.30), diabetes mellitus ( OR, 1.98), obesity ( OR, 2.29), and high serum triglyceride levels ( OR, 1.47) was significantly higher in the first than in the fourth quartile of serum 25( OH) D levels ( P < .001 for all).Conclusions: Serum 25( OH) D levels are associated with important cardiovascular disease risk factors in US adults. Prospective studies to assess a direct benefit of cholecalciferol ( vitamin D) supplementation on cardiovascular disease risk factors are warranted.