Heritability of adult body height:: A comparative study of twin cohorts in eight countries
Heritability of adult body height:: A comparative study of twin cohorts in eight countries
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DOI：
10.1375/twin.6.5.399
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发表时间：
2003-10-01
期刊：
影响因子：
--
通讯作者：
Kaprio, J
中科院分区：
文献类型：
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作者：
Silventoinen, K;Sammalisto, S;Kaprio, J
身高差异的一个主要组成部分是由于遗传差异，但环境因素也有很大的贡献作用。在这项研究中，我们旨在分析富裕的西方社会之间身高的遗传结构是否存在差异。我们使用Mx统计软件包的单变量遗传模型分析了来自8个国家的30，111对完整双胞胎数据。在7个群体中自我报告身高和接合性，并在一个群体中直接测量。我们发现，国家之间的平均身高有很大的差异;意大利的身高最低（男性177 cm，女性163 cm），荷兰最高（分别为184 cm和171 cm）。在男性中，身高的遗传力没有相应的变化，在加性基因/独特环境（AE）模型下，遗传力估计值范围为0.87至0.93。在妇女中的遗传力估计值普遍低于男性之间的差异更大的国家之间，从0.68至0.84时，使用的加性基因/共享环境/独特的环境（ACE）模型。在AE模型拟合同样好或更好的四个人群中，遗传力范围为0.89至0.93。性别之间的这种差异主要是由于方差的共享环境成分的影响，这似乎是更重要的女性比男性在我们的研究人群。我们的研究结果表明，在一般情况下，只有微小的差异，在富裕的高加索人群，特别是男性之间的遗传结构的高度。
A major component of variation in body height is due to genetic differences, but environmental factors have a substantial contributory effect. In this study we aimed to analyse whether the genetic architecture of body height varies between affluent western societies. We analysed twin data from eight countries comprising 30,111 complete twin pairs by using the univariate genetic model of the Mx statistical package. Body height and zygosity were self-reported in seven populations and measured directly in one population. We found that there was substantial variation in mean body height between countries; body height was least in Italy (177 cm in men and 163 cm in women) and greatest in the Netherlands (184 cm and 171 cm, respectively). In men there was no corresponding variation in heritability of body height, heritability estimates ranging from 0.87 to 0.93 in populations under an additive genes/unique environment (AE) model. Among women the heritability estimates were generally lower than among men with greater variation between countries, ranging from 0.68 to 0.84 when an additive genes/shared environment/unique environment (ACE) model was used. In four populations where an AE model fit equally well or better, heritability ranged from 0.89 to 0.93. This difference between the sexes was mainly due to the effect of the shared environmental component of variance, which appears to be more important among women than among men in our study populations. Our results indicate that, in general, there are only minor differences in the genetic architecture of height between affluent Caucasian populations, especially among men.