The interval from surgery to chemotherapy in the treatment of advanced epithelial ovarian carcinoma
The interval from surgery to chemotherapy in the treatment of advanced epithelial ovarian carcinoma
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DOI：
10.1016/j.ejso.2006.02.013
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发表时间：
2006-06-01
期刊：
影响因子：
3.8
通讯作者：
Jayson, GC
中科院分区：
文献类型：
--
作者：
Rosa, DD;Clamp, A;Jayson, GC
背景资料：研究手术与化疗开始间隔时间对晚期卵巢癌患者治疗的影响。方法：我们根据铂类药物化疗的开始时间将患者分为第1组（术后4周内），第2组结果：共分析了394例III期卵巢癌患者。在多变量分析中，根据手术和化疗之间的时间间隔，三组之间的生存率没有差异。独立预后变量为手术类型（p=0.014）、体力状态（p=0.040）和化疗后CA-125（p
Background: To study the effect of the interval between surgery and the start of chemotherapy in the treatment of patients with advanced ovarian cancer.Methods: We stratified patients according to the start of platinum-based chemotherapy in group 1 (within 4 weeks from surgery), group 2 (between 4 and 8 weeks) and group 3 (between 8 and 12 weeks).Results: Three hundred and ninty-four stage III ovarian cancer patients were analysed. In the multivariate analysis there were no differences in survival according to the interval between surgery and chemotherapy among the three groups. The independent prognostic variables were type of procedure (p=0.014), performance status (p=0.040) and post-chemotherapy CA-125 (p