Bacterial and fungal infections in acute-on-chronic liver failure: prevalence, characteristics and impact on prognosis
Bacterial and fungal infections in acute-on-chronic liver failure: prevalence, characteristics and impact on prognosis
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DOI：
10.1136/gutjnl-2017-314240
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发表时间：
2018-10-01
期刊：
影响因子：
24.5
通讯作者：
Arroyo, Vicente
中科院分区：
文献类型：
--
作者：
Fernandez, Javier;Acevedo, Juan;Arroyo, Vicente
细菌感染是慢性加急性肝衰竭（ACLF）的常见诱因，ACLF综合征也可能增加感染的风险。本研究对407例ACLF患者和235例急性失代偿期（AD）患者进行了细菌和真菌感染的流行病学调查，分析了ACLF患者细菌和真菌感染的流行病学特征、预测因素以及细菌感染对患者生存的影响。其余255例ACLF患者中有46%（n=117）在随访期间（4周）发生细菌感染。AD患者的相应数字分别为25%和18%（p < 0.01）。
Bacterial infection is a frequent trigger of acute-on-chronic liver failure (ACLF), syndrome that could also increase the risk of infection. This investigation evaluated prevalence and characteristics of bacterial and fungal infections causing and complicating ACLF, predictors of follow-up bacterial infections and impact of bacterial infections on survival.Patients 407 patients with ACLF and 235 patients with acute decompensation (AD).Results 152 patients (37%) presented bacterial infections at ACLF diagnosis; 46%(n=117) of the remaining 255 patients with ACLF developed bacterial infections during follow-up (4 weeks). The corresponding figures in patients with AD were 25% and 18% (p