Influence of immediate and early loading on bone metabolic activity around dental implants in rat tibiae
Influence of immediate and early loading on bone metabolic activity around dental implants in rat tibiae
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即刻和早期负重对大鼠胫骨牙种植体周围骨代谢活性的影响
DOI：
10.1111/clr.12218
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Sasaki K.
中科院分区：
文献类型：
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作者：
Yamamoto M;Ogawa T;Yokoyama M;Koyama S;Sasaki K.
目的本研究的目的是利用骨闪烁扫描技术检查即刻和早期负重对牙种植体周围骨代谢动态变化的影响。材料和方法将两个钛种植体植入21只大鼠的右侧胫骨中。将具有 4.0 N 载荷的闭合螺旋弹簧平行施加到植入物的上部，持续 35 天。根据负载施加时间，将大鼠分为三组：即刻负载（IL）组、种植体植入后1天早期负载（1-D早期负载[EL]）组和种植体植入后3天负载（3-D EL）组。给大鼠静脉注射锝-99 m-亚甲基二磷酸盐 (Tc99 m-MDP)（74 MBq/大鼠），并在施加负荷后 1、4、7、11、14、21、28 和 35 天通过骨闪烁扫描进行扫描。计算种植体周围 Tc99 m-MDP 积累与参考部位积累的比率（摄取比率），以评估骨代谢。结果在各组中，摄取比率直到施加负载后 7 天才增加，然后逐渐下降。第 4、7、11 和 14 天时显着高于基线 (P<0.001)。 1-D EL 和 3-D EL 组的摄取率显着高于对照组和 IL 组（P < 0.001）。结论 尽管负荷时间存在差异，但骨代谢最初增加，然后逐渐下降至基线。骨代谢活动的增加根据负荷施加时间的不同而不同；负荷施加越晚，骨代谢越增强。
ObjectivesThe aim of this study was to examine the influence of immediate and early loading on dynamic changes in bone metabolism around dental implants using bone scintigraphy.Material and methodsTwo titanium implants were inserted in the right tibiae of 21 rats. Closed coil springs with 4.0‐N loads were applied parallel to the upper portion of the implants for 35 days. According to the load application timing, rats were divided into three groups: immediate loading (IL) group, early loading 1 day after implant insertion (1‐D early loading [EL]) group, and loading 3 days after implant insertion (3‐D EL) group. Rats were intravenously injected with technetium‐99 m‐methylene diphosphonate (Tc99 m‐MDP) (74 MBq/rat) and scanned by bone scintigraphy at 1, 4, 7, 11, 14, 21, 28, and 35 days after load application. The ratio of accumulation of Tc99 m‐MDP around the implants to that of a reference site (uptake ratio) was calculated to evaluate bone metabolism.ResultsIn every group, the uptake ratio increased until 7 days after load application and then gradually decreased. It was significantly higher than baseline at 4, 7, 11, and 14 days (P< 0.001). The uptake ratio in the 1‐D EL and 3‐D EL groups were significantly higher than that in the control group and also that in the IL group (P< 0.001).ConclusionsBone metabolism initially increased and then gradually decreased to baseline despite differences in load timing. Increases in bone metabolic activity differed according to load application timing; the later the load application, the more enhanced the bone metabolism.