THERAPEUTIC DECISION-MAKING - COST-BENEFIT ANALYSIS
THERAPEUTIC DECISION-MAKING - COST-BENEFIT ANALYSIS
复制标题
DOI：
10.1056/nejm197507312930505
复制
发表时间：
1975-01-01
影响因子：
158.5
通讯作者：
KASSIRER, JP
中科院分区：
文献类型：
--
作者：
PAUKER, SG;KASSIRER, JP
为了帮助医生决定是否治疗可能患有或可能没有疾病的患者，已经开发了一种计算治疗阈值的方法。如果给定患者的患病概率超过阈值，则更可取的行动方案是治疗；如果概率低于阈值，则更可取的行动方案是暂停治疗。这种方法适用于许多内科和外科环境，在这些环境中，在进行了所有适当的研究之后存在一些诊断不确定性。该技术不仅揭示了面对诊断不确定性时治疗决策的一些基本原则，而且形成了一个方便的框架，用于分析“软”临床数据对决策过程的影响。(N Engl J Med 293：229-234,1975)
To help the physician decide whether or not to treat a patient who may or may not have a disease, a method has been developed for calculating a therapeutic threshold. If the probability of disease in a given patient exceeds the threshold, the preferable course of action is to treat; if the probability is below the threshold, the preferable course of action is to withhold treatment. This method is applicable in many medical and surgical settings in which some diagnostic uncertainty exists after all appropriate studies have been carried out. The technic not only exposes some of the basic principles of therapeutic decision making in the face of diagnostic uncertainty but also forms a convenient framework for analyzing the impact of "soft" clinical data on the decision-making process. (N Engl J Med 293:229–234, 1975)