Multisensory interactions within human primary cortices revealed by BOLD dynamics
Multisensory interactions within human primary cortices revealed by BOLD dynamics
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DOI：
10.1093/cercor/bhl077
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发表时间：
2007-07-01
期刊：
影响因子：
3.7
通讯作者：
Meuli, Reto A.
中科院分区：
文献类型：
--
作者：
Martuzzi, Roberto;Murray, Micah M.;Meuli, Reto A.
尽管在动物身上发现了新的证据，但来自不同感觉方式的信号是否会在人类的初级皮质内汇聚并相互作用还没有得到解决。这部分是因为关于功能性磁共振成像（fMRI）数据在多感觉现象中的适当分析的争论。使用事件相关的功能磁共振成像，我们观察到，简单的听觉刺激（噪音爆发）激活初级视觉皮层和简单的视觉刺激（棋盘）激活初级听觉皮层，多感觉会聚的指示。此外，血氧水平依赖性反应动力学的分析表明，促进血流动力学反应峰值lavelian和斜率的多感觉神经视觉刺激与任一unisensory条件下，表明多感觉相互作用的初级感觉皮层。在最低皮层水平的神经处理可以通过感觉之间的相互作用来调节。功能磁共振成像数据中的时间信息可以揭示这些调制，并克服更传统的程序的分析和解释的挑战。除了提供一个必要的翻译与动物模型的联系，这些结果表明，长期以来的概念皮层组织需要修改，包括多感官的相互作用作为一个固有的组成部分，功能性脑组织。
Whether signals from different sensory modalities converge and interact within primary cortices in humans is unresolved, despite emerging evidence in animals. This is partially because of debates concerning the appropriate analyses of functional magnetic resonance imaging (fMRI) data in response to multisensory phenomena. Using event-related fMRI, we observed that simple auditory stimuli (noise bursts) activated primary visual cortices and that simple visual stimuli (checkerboards) activated primary auditory cortices, indicative of multisensory convergence. Moreover, analyses of blood oxygen level-dependent response dynamics revealed facilitation of hemodynamic response peak latencies and slopes for multisensory auditory-visual stimuli versus either unisensory condition, indicative of multisensory interactions within primary sensory cortices. Neural processing at the lowest cortical levels can be modulated by interactions between the senses. Temporal information in fMRI data can reveal these modulations and overcome analytic and interpretational challenges of more traditional procedures. In addition to providing an essential translational link with animal models, these results suggest that longstanding notions of cortical organization need to be revised to include multisensory interactions as an inherent component of functional brain organization.