Computational modelling of electrocardiograms: repolarisation and T-wave polarity in the human heart.
Computational modelling of electrocardiograms: repolarisation and T-wave polarity in the human heart.
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DOI：
10.1080/10255842.2012.729582
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发表时间：
2014
影响因子：
1.6
通讯作者：
Kuhl E
中科院分区：
文献类型：
--
作者：
Hurtado DE;Kuhl E
世纪以来，电生理学家、心脏病学家和工程师一直在研究人类心脏的电活动，以更好地了解心律失常和可能的治疗方案。虽然心脏的去极化序列是相对较好的特点，复极序列仍然是一个有很大争议的主题。在这里，我们研究区域和时间的变化，去极化和复极使用有限元方法。我们离散的控制方程在时间上使用一个无条件稳定的隐式欧拉向后计划，并在空间上使用一致的线性化牛顿-拉夫逊为基础的有限元求解器。通过系统的参数敏感性研究，我们建立了一个正常的正T波和非均匀分布的控制参数，我们称之为不应期之间的直接关系。为了建立一个健康的基线模型，我们使用临床测量的动作电位时程在不同位置的人的心脏校准不应期。我们通过比较计算预测和临床测量的左心室去极化和复极曲线来证明我们模型的潜力。建议的框架，使我们能够探索如何在微观尺度上的局部动作电位持续时间转化为全球复极序列的宏观尺度上。我们预计，我们校准的人类心脏模型可以广泛用于探索健康和疾病中的心脏兴奋。例如，我们的模型可以用于识别心力衰竭患者的最佳起搏部位，并定位心脏颤动患者的最佳消融部位。
For more than a century, electrophysiologists, cardiologists, and engineers have studied the electrical activity of the human heart to better understand rhythm disorders and possible treatment options. While the depolarization sequence of the heart is relatively well characterized, the repolarization sequence remains a subject of great controversy. Here we study regional and temporal variations in both depolarization and repolarization using a finite element approach. We discretize the governing equations in time using an unconditionally stable implicit Euler backward scheme and in space using a consistently linearized Newton-Raphson-based finite element solver. Through systematic parameter-sensitivity studies, we establish a direct relation between a normal positive T-wave and the non-uniform distribution of the controlling parameter, which we have termed refractoriness. To establish a healthy baseline model, we calibrate the refractoriness using clinically measured action potential durations at different locations in the human heart. We demonstrate the potential of our model by comparing the computationally predicted and clinically measured depolarization and repolarization profiles across the left ventricle. The proposed framework allows us to explore how local action potential durations on the microscopic scale translate into global repolarization sequences on the macroscopic scale. We anticipate that our calibrated human heart model can be widely used to explore cardiac excitation in health and disease. For example, our model can serve to identify optimal pacing sites in patients with heart failure and to localize optimal ablation sites in patients with cardiac fibrillation.
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影响因子：
1.3
作者：
Bacharova, Ljuba;Mateasik, Anton;Potse, Mark
通讯作者：
Potse, Mark
DOI：
10.1152/ajpheart.01241.2010
发表时间：
2011-07-01
影响因子：
4.8
作者：
Okada, Jun-ichi;Washio, Takumi;Hisada, Toshiaki
通讯作者：
Hisada, Toshiaki
影响因子：
7.8
作者：
Aliev, RR;Panfilov, AV
通讯作者：
Panfilov, AV
DOI：
10.1080/10255842.2011.554410
发表时间：
2012-01-01
影响因子：
1.6
作者：
Dal, Huesnue;Goktepe, Serdar;Kuhl, Ellen
通讯作者：
Kuhl, Ellen
影响因子：
3.4
作者：
FITZHUGH, R
通讯作者：
FITZHUGH, R