Total lymphoid and local joint irradiation in the treatment of adjuvant arthritis.
Total lymphoid and local joint irradiation in the treatment of adjuvant arthritis.
复制标题
全淋巴和局部关节照射治疗佐剂性关节炎。
作者：
D. Schurman;H. Hirshman;S. Strober
采用 3,400 rad 分 17 次全淋巴照射 (TLI)、600 rad 分 3 次局部爪照射、或同时使用 TLI 和局部照射来治疗患有佐剂性关节炎的 Lewis 大鼠。与对照组相比，单独 TLI 或局部爪子照射可适度降低关节炎的严重程度（P < 0.05）。 TLI 治疗的动物对炎症有更多的初始抑制。联合 TLI 和局部爪照射治疗的辅助大鼠的炎症和永久性关节炎显着而持久地减少 (P < 0.001)。
Total lymphoid irradiation (TLI) with 3,400 rads delivered in 17 divided doses, 600 rads at local paw irradiation in 3 divided doses, or both TLI and local irradiation were used to treat Lewis rats with adjuvant arthritis. Either TLI alone or local paw irradiation modestly reduced the severity of arthritis compared to a control group (P < 0.05). TLI treated animals had more initial suppression of inflammation. Adjuvant rats treated with a combination of both TLI and local paw irradiation had a profound and long lasting reduction in inflammation and permanent arthritis (P < 0.001).