Long-term neurodevelopmental outcome of 167 children after intrauterine laser treatment for severe twin-twin transfusion syndrome
Long-term neurodevelopmental outcome of 167 children after intrauterine laser treatment for severe twin-twin transfusion syndrome
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DOI：
10.1016/j.ajog.2005.07.040
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发表时间：
2006-02-01
影响因子：
9.8
通讯作者：
Bartmann, P
中科院分区：
文献类型：
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作者：
Graef, C;Ellenrieder, B;Bartmann, P
目的：探讨重度双胎输血综合征宫内激光凝血术后新生儿的长期神经发育结局。研究设计：167名幸存的婴儿在1997年6月至1999年9月间接受治疗，平均年龄为3岁零2个月。所有的孩子都接受了详细的标准化的身体和神经系统检查以及标准化的发育测试（格里菲斯发育测试量表和斯尼德斯-欧曼非语言智力测试）。结果：发育正常145例（86.8%），轻度神经异常12例（7.2%），重度神经异常10例（6.0%）。前捐赠者/接受者的结果没有差异（P = .349），双胞胎或单胎婴儿的结果没有差异（P = .088）。结论：宫内激光凝血术治疗严重双胎输血综合征的最佳方法是正常神经发育发生率高达86.8%，严重神经功能缺陷发生率仅为6.0%。(c) 2006 Mosby, Inc。版权所有。
Objective: This study was undertaken to investigate long-term neurodevelopmental outcome of children born after intrauterine laser coagulation for severe twin-twin transfusion syndrome syndrome.Study design: One hundred sixty-seven surviving infants treated between June 1997 and September 1999 were investigated at a median age of 3 years and 2 months. All children underwent a detailed standardized physical and neurologic examination and a standardized developmental test (Griffiths' Developmental Test Scales and Snijders-Oomen Non-Verbal-Intelligence Test).Results: One hundred forty-five infants (86.8%) showed normal development, 12 infants (7.2%) showed minor neurologic abnormalities, and 10 infants (6.0%) major neurologic abnormalities. There was no difference in outcome for the former donors/recipients (P = .349) and between infants who were born as twins or singletons (P = .088).Conclusion: With a high rate (86.8%) of normal neurodevelopmental outcome and an incidence of only 6.0% of major neurologic deficiencies, intrauterine laser coagulation seems to be the best treatment option for severe twin-twin transfusion syndrome. (c) 2006 Mosby, Inc. All rights reserved.