Context-Dependent Enhancer Selection Confers Alternate Modes of Notch Regulation on argos
Context-Dependent Enhancer Selection Confers Alternate Modes of Notch Regulation on argos
复制标题
DOI：
10.1128/mcb.01045-13
复制
发表时间：
2014-02-01
影响因子：
5.3
通讯作者：
Bray, Sarah J.
中科院分区：
文献类型：
--
作者：
Housden, Benjamin E.;Terriente-Felix, Ana;Bray, Sarah J.
信号通路之间的连接根据环境而不同，例如Notch和表皮生长因子受体（EGFR）通路之间的相互作用，它们在某些情况下是合作的，但在其他情况下是拮抗的。为了研究不同相声模式的机制，我们重点研究了黑腹果蝇（Drosophila melanogaster）的EGFR通路调节因子argos，它在成年肌肉祖细胞中被Notch上调，但在翅膀中被抑制。结果表明，串扰的交替模式取决于具有相反调控逻辑的增强子的参与，这些增强子是由环境决定因素选择的。这可能是一种通用机制，使这些通路之间的连接能够根据上下文切换。
Wiring between signaling pathways differs according to context, as exemplified by interactions between Notch and epidermal growth factor receptor (EGFR) pathways, which are cooperative in some contexts but antagonistic in others. To investigate mechanisms that underlie different modes of cross talk, we have focused on argos, an EGFR pathway regulator in Drosophila melanogaster which is upregulated by Notch in adult muscle progenitors but is repressed in the wing. Results show that the alternate modes of cross talk depend on the engagement of enhancers with opposite regulatory logic, which are selected by context-determining factors. This is likely to be a general mechanism for enabling the wiring between these pathways to switch according to context.