Volumetric development of hippocampal subfields and hippocampal white matter connectivity: Relationship with episodic memory.
Volumetric development of hippocampal subfields and hippocampal white matter connectivity: Relationship with episodic memory.
复制标题
海马亚区的体积发育和海马白质连接：与情景记忆的关系。
DOI：
10.1002/dev.22333
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发表时间：
2022
影响因子：
2.2
通讯作者：
Mattfeld,AaronT
中科院分区：
文献类型：
--
作者：
Dick,AnthonySteven;Ralph,Yvonne;Farrant,Kristafor;Reeb-Sutherland,Bethany;Pruden,Shannon;Mattfeld,AaronT
海马是一个复杂的结构，由不同的子领域组成。它对于理解情景记忆的神经基础至关重要。在当前的横断面研究中，使用来自独特的公开数据集的830名3至21奥尔兹的大样本，我们研究了以下问题：（1）与早期发育相比，海马体和子区域的灰质体积是否增加？(2)在不同的发育阶段，海马体的体积与大脑皮层的其他部分相比如何？（3）海马体积和连接性与情节记忆成绩的关系。我们发现海马子区体积与年龄呈非线性关系，并且与相邻皮质区域（例如，内嗅皮层）。我们还观察到老年组的皮质体积显著减少，而海马体积显示出相反的模式。除了年龄相关的灰质体积差异外，齿状回/氨角3体积与情景记忆显著相关。然而，我们没有发现任何关联与情节记忆的表现和连接通过钩束，穹窿，或扣带。结果进行了讨论的背景下，目前的研究和理论的海马发展及其与情节记忆。
The hippocampus is a complex structure composed of distinct subfields. It has been central to understanding neural foundations of episodic memory. In the current cross‐sectional study, using a large sample of 830, 3‐ to 21‐year‐olds from a unique, publicly available dataset we examined the following questions: (1) Is there elevated grey matter volume of the hippocampus and subfields in late compared to early development? (2) How does hippocampal volume compare with the rest of the cerebral cortex at different developmental stages? and (3) What is the relation between hippocampal volume and connectivity with episodic memory performance? We found hippocampal subfield volumes exhibited a nonlinear relation with age and showed a lag in volumetric change with age when compared to adjacent cortical regions (e.g., entorhinal cortex). We also observed a significant reduction in cortical volume across older cohorts, while hippocampal volume showed the opposite pattern. In addition to age‐related differences in gray matter volume, dentate gyrus/cornu ammonis 3 volume was significantly related to episodic memory. We did not, however, find any associations with episodic memory performance and connectivity through the uncinate fasciculus, fornix, or cingulum. The results are discussed in the context of current research and theories of hippocampal development and its relation to episodic memory.