Route learning performance in Alzheimer disease patients.
Route learning performance in Alzheimer disease patients.
复制标题
阿尔茨海默病患者的路线学习表现。
DOI：
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
K. Perryman
中科院分区：
文献类型：
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作者：
M. Cherrier;M. Mendez;K. Perryman
目的
研究阿尔茨海默病（AD）患者路径学习的客观指标。
背景
地形定向障碍（TD）是AD患者的常见问题。导致AD患者TD的潜在认知缺陷尚不清楚。
方法
本研究对19名健康老年人（对照组）和16名AD患者进行了全面的神经心理学测试沿着新的路径学习测试（RLT）。评估的领域包括附带学习，空间关系。回忆行走路线和识别地标。
结果
尽管基本的视觉空间能力指标的表现相当，AD患者的表现显着不如对照组的RLT和证明穷人的附带学习环境的细节。以自我为中心和以他人为中心的定向能力是AD患者RLT表现的最佳预测因子。在RLT子测试中，与空间布局的识别和回忆或环境中偶然项目的识别相比，AD患者在识别地标方面表现最好。
结论
我们的研究结果表明，AD患者在RLT上的表现不佳是空间定向或空间推理能力差的特征。因此，AD患者的TD发作可能继发于空间定向不良。
OBJECTIVE
To examine performance on an objective measure of route learning in Alzheimer disease (AD) patients.
BACKGROUND
Topographic disorientation (TD) is a common problem among AD patients. The underlying cognitive deficits that contribute to TD in AD patients are not well understood.
METHOD
This study examined 19 healthy older individuals (controls) and 16 AD patients who were administered a comprehensive neuropsychological battery along with a novel Route Learning Test (RLT). Areas assessed included incidental learning, spatial relations. recall of the walking route, and recognition of landmarks.
RESULTS
Despite comparable performance on basic visuospatial ability measures, AD patients performed significantly worse than controls on the RLT and evidenced poor incidental learning for environmental details. A measure of egocentric and allocentric orientation ability was the best predictor of RLT performance in AD patients. Among RLT subtests, AD patients performed best on recognition of landmarks compared with recognition and recall of spatial layout or recognition of incidental items in the environment.
CONCLUSIONS
Our findings suggest that poor performance on the RLT in AD patients is characteristic of poor spatial orientation or spatial reasoning. Therefore, episodes of TD in AD patients may occur secondary to poor spatial orientation.