Mapping postnatal mouse brain development with diffusion tensor microimaging
Mapping postnatal mouse brain development with diffusion tensor microimaging
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DOI：
10.1016/j.neuroimage.2005.03.009
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发表时间：
2005-07-15
期刊：
影响因子：
5.7
通讯作者：
Mori, S
中科院分区：
文献类型：
--
作者：
Zhang, JY;Miller, MI;Mori, S
虽然利用组织学对小鼠脑发育进行了广泛的研究，但形态学变化的定量表征仍然是一项具有挑战性的任务。本文介绍了如何利用磁共振扩散张量微成像结合计算解剖学技术定量表征发育中的大脑结构。高分辨率的弥散张量图像为揭示小鼠前脑结构的进化提供了良好的对比。利用弥散张量图像定义的解剖标志，定量小鼠脑组织水平的生长模式。结果表明，使用这些技术来三维和定量表征大脑生长。(c) 2005爱思唯尔公司版权所有。
While mouse brain development has been extensively studied using histology, quantitative characterization of morphological changes is still a challenging task. This paper presents how developing brain structures can be quantitatively characterized with magnetic resonance diffusion tensor microimaging coupled with techniques of computational anatomy. High resolution diffusion tensor images of ex vivo postnatal mouse brains provide excellent contrasts to reveal the evolutions of mouse forebrain structures. Using anatomical landmarks defined on diffusion tensor images, tissue level growth patterns of mouse brains were quantified. The results demonstrate the use of these techniques to three-dimensionally and quantitatively characterize brain growth. (c) 2005 Elsevier Inc. All rights reserved.