RISK OF CHILDHOOD-CANCER FOR INFANTS WITH BIRTH-DEFECTS .2. A RECORD-LINKAGE STUDY, IOWA, 1983-1989
RISK OF CHILDHOOD-CANCER FOR INFANTS WITH BIRTH-DEFECTS .2. A RECORD-LINKAGE STUDY, IOWA, 1983-1989
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DOI：
10.1093/oxfordjournals.aje.a116721
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发表时间：
1993-03-15
影响因子：
5
通讯作者：
EDMONDS, LD
中科院分区：
文献类型：
--
作者：
MILI, F;LYNCH, CF;EDMONDS, LD
为了证实在乔治亚州亚特兰大进行的一项相关研究中发现的唐氏综合症与急性白血病、幽门狭窄与儿童癌症之间的联系，作者利用爱荷华州健康登记处将1983年至1989年患癌症的婴儿和儿童的记录与1983年至1988年出生缺陷婴儿的记录联系起来。在研究期间，10891名1岁以下的婴儿被诊断出出生缺陷，396名8岁以下的儿童被诊断出癌症。作者将观察到的有缺陷的儿童患癌症的人数与基于癌症登记率的预期人数进行了比较。在10,891名有出生缺陷的儿童中，16名发生了癌症(标准化发病率（SIR) = 2.0, 95%可信区间（Cl） 1.2-3.3）。251名患有唐氏综合症（21三体）的儿童中，2名发展为白血病（SIR = 32.1, 95% Cl = 3.9-116.0）。所有癌症患儿均无幽门狭窄（SIR = 0.0, 95% Cl = 0.0-6.7）。这项研究的结果支持亚特兰大研究中发现的唐氏综合症与白血病之间的联系，但不支持幽门狭窄与儿童癌症之间的联系。然而，与亚特兰大的研究相比，这项研究的随访时间更短，受试者数量也更少。
To attempt to confirm associations found in a companion study in Atlanta, Georgia between Down's syndrome and acute leukemia and between pyloric stenosis and childhood cancer, the authors used the State Health Registry of Iowa to link the records of infants and children with cancer for 1983 to 1989 with the records of infants with birth defects for 1983 to 1988. During the study period, birth defects were diagnosed in 10,891 infants younger than 1 year of age, and cancer was diagnosed in 396 children younger than 8 years of age. The authors compared the observed number of children with a defect who developed cancer with the number expected on the basis of the cancer registry rates. Of the 10,891 children with birth defects, 16 developed cancer (standardized incidence ratio (SIR) = 2.0, 95% confidence interval (Cl) 1.2-3.3). Of 251 children with Down's syndrome (trisomy 21), two developed leukemia (SIR = 32.1, 95% Cl 3.9-116.0). None of the infants with cancer had pyloric stenosis (SIR = 0.0, 95% Cl 0.0-6.7). The results of this study supported the association found in the Atlanta study between Down's syndrome and leukemia, but did not support the association found there between pyloric stenosis and childhood cancer. This study, however, had a shorter follow-up period and a smaller number of subjects than the Atlanta study.