Engaging neuroscience to advance translational research in brain barrier biology.
Engaging neuroscience to advance translational research in brain barrier biology.
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DOI：
10.1038/nrn2995
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发表时间：
2011-03
影响因子：
34.7
通讯作者：
Drewes, Lester R.
中科院分区：
文献类型：
--
作者：
Neuwelt, Edward A.;Bauer, Bjoern;Fahlke, Christoph;Fricker, Gert;Iadecola, Constantino;Janigro, Damir;Leybaert, Luc;Molnar, Zoltan;O'Donnell, Martha E.;Povlishock, John T.;Saunders, Norman R.;Sharp, Frank;Stanimirovic, Danica;Watts, Ryan J.;Drewes, Lester R.
许多潜在的治疗和诊断化合物向大脑特定区域的输送受到脑屏障的限制，其中最著名的是血脑屏障（BBB）和血脑脊液（CSF）屏障。最近的研究显示了这些屏障的许多其他作用，包括参与神经发育，控制脑血流，并且，当屏障完整性受损时，对许多常见的中枢神经系统疾病（如阿尔茨海默病，帕金森病和中风）的病理有贡献。因此，神经科学研究的许多关键领域都与“脑屏障科学”共享。然而，尽管有这种重叠，却很少有相声。由于我们对神经血管单元（NVU）（由局部神经元回路、胶质细胞、周细胞和内皮组成）的新认识，这种缺乏串扰的现象不仅具有学术意义，而且说明了大脑如何动态调节其血流、代谢和电生理调节。一个关键的见解是，屏障是NVU的重要组成部分，因此受到该单元所有细胞元素的影响。
The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, the most well known of which are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, control of cerebral blood flow, and, when barrier integrity is impaired, a contribution to the pathology of many common CNS disorders such as Alzheimer’s disease, Parkinson’s disease and stroke. Thus, many key areas of neuroscientific investigation are shared with the ‘brain barriers sciences’. However, despite this overlap there has been little crosstalk. This lack of crosstalk is of more than academic interest as our emerging understanding of the neurovascular unit (NVU), composed of local neuronal circuits, glia, pericytes and the endothelium, illustrates how the brain dynamically modulates its blood flow, metabolism, and electrophysiological regulation. A key insight is that the barriers are an essential part of the NVU and as such are influenced by all cellular elements of this unit.
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影响因子：
2.9
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
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发表时间：
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作者：
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