Cure of Helicobacter pylori infection and duration of remission of low-grade gastric mucosa-associated lymphoid tissue lymphoma.
Cure of Helicobacter pylori infection and duration of remission of low-grade gastric mucosa-associated lymphoid tissue lymphoma.
复制标题
幽门螺杆菌感染的治愈和低度胃粘膜相关淋巴组织淋巴瘤的缓解持续时间。
DOI：
--
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
M. Stolte
中科院分区：
文献类型：
--
作者：
A. Neubauer;C. Thiede;B. Alpen;M. Ritter;B. Neubauer;G. Ehninger;A. Morgner;E. Bayerdörffer;T. Wündisch;M. Stolte
背景
粘膜相关淋巴组织 (MALT) 中产生的低度 B 细胞淋巴瘤最常见于胃肠道。超过 90% 的胃 MALT 淋巴瘤是在患有慢性幽门螺杆菌相关胃炎的患者中诊断出来的。幽门螺杆菌感染治愈后，这些淋巴瘤的缓解率很高。然而，缺乏关于缓解持续时间的数据。为了解决缓解持续时间的问题，我们对 50 名幽门螺杆菌感染被根除的患者进行了随访，并确定完全缓解的患者在随访期间是否显示出残留单克隆 B 细胞的证据。
方法
患者接受阿莫西林和奥美拉唑治疗两周，试图治愈幽门螺杆菌感染。随访包括内窥镜检查和活检取样。通过基于聚合酶链式反应 (PCR) 的检测方法检测活检标本中的单克隆 B 细胞。
结果
50 名患者全部治愈幽门螺杆菌感染。目前，这 50 名患者的中位随访时间为 24 个月（729 天；范围为 135-1411 天）。四十名患者的淋巴瘤得到完全缓解，但五名患者随后复发。 40 名患者持续完全缓解的中位时间为 15.4 个月（468 天；范围：0-1198 天）。在六名淋巴瘤患者对幽门螺杆菌根除没有反应的患者中，四名患者在手术后发现高级别淋巴瘤。 PCR 表明，在 31 名可评估的完全缓解患者中，有 22 名患者在随访期间存在单克隆 B 细胞。
结论
幽门螺杆菌感染治愈后，低度胃 MALT 淋巴瘤的完全缓解似乎是稳定的，尽管大多数患者在随访期间显示出单克隆 B 细胞的证据。这些患者的淋巴瘤是否真正治愈仍有待确定。
BACKGROUND
Low-grade B-cell lymphomas arising in mucosa-associated lymphoid tissue (MALT) are most frequently localized in the gastrointestinal tract. More than 90% of gastric MALT lymphomas are diagnosed in patients with chronic, Helicobacter pylori-associated gastritis. High remission rates for these lymphomas have been observed after the cure of H. pylori infection. Data are lacking, however, with regard to the duration of the remissions. To address this question of remission duration, we have followed 50 patients in whom H. pylori infections were eradicated, and we determined whether the patients in complete remission displayed evidence of residual monoclonal B cells during follow-up.
METHODS
Patients were treated with amoxycillin and omeprazole for 2 weeks in an attempt to cure H. pylori infections. Follow-up included endoscopic investigations with biopsy sampling. Monoclonal B cells in biopsy specimens were detected by means of a polymerase chain reaction (PCR)-based assay.
RESULTS
H. pylori infections were cured in all 50 patients. The median follow-up for the 50 patients is currently 24 months (729 days; range, 135-1411 days). Forty patients achieved complete remission of their lymphomas, but five have subsequently relapsed. The median time of continuous complete remission for the 40 patients was 15.4 months (468 days; range, 0-1198 days). Among six patients whose Iymphomas did not respond to H. pylori eradication, four revealed high-grade lymphomas upon surgery. PCR indicated the presence of monoclonal B cells during follow-up in 22 of 31 assessable patients in complete remission.
CONCLUSIONS
Complete remissions of low-grade gastric MALT Iymphomas after the cure of H. pylori infection appear to be stable, although most patients display evidence of monoclonal B cells during follow-up. Whether these patients are truly cured of their Iymphomas remains to be determined.
慢性粒细胞白血病进化过程中的分子变化谱。
DOI：
10.1172/jci115234
发表时间：
1991
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Ahuja,H;Bar-Eli,M;Arlin,Z;Advani,S;Allen,SL;Goldman,J;Snyder,D;Foti,A;Cline,M
通讯作者：
Cline,M