A second look at comorbidity in victims of trauma: The posttraumatic stress disorder-major depression connection
A second look at comorbidity in victims of trauma: The posttraumatic stress disorder-major depression connection
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DOI：
10.1016/s0006-3223(00)00933-1
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发表时间：
2000-11-01
影响因子：
10.6
通讯作者：
Schultz, LR
中科院分区：
文献类型：
--
作者：
Breslau, N;Davis, GC;Schultz, LR
背景：我们研究创伤事件是否会增加重度抑郁症的风险，而与创伤后应激障碍 (PTSD) 的影响无关。方法：数据来自密歇根州东南部年轻人的流行病学研究 (N = 1007)。使用回顾性和前瞻性数据来估计患有 PTSD 的人和没有经历过 PTSD 的创伤者与没有经历过创伤的人相比，患重度抑郁症的风险。国家合并症调查数据用于评估创伤类型的影响。 结果：在回顾性一生数据中，与未接触过的人相比，患有 PTSD 的接触过的人首次发病重性抑郁的风险比为 2.8，无 PTSD 的接触过的人为 1.3（不显着）。前瞻性数据的相应估计值为 11.7 和 1.4（不显着）。与 PTSD 相关的抑郁症风险与没有 PTSD 的暴露者相比，不太可能是由于创伤类型的差异所致。结论：患有 PTSD 的人患重度抑郁症的风险显着增加，但没有 PTSD 的暴露者则没有，这一发现并不支持创伤受害者的 PTSD 和重度抑郁症受不同脆弱性影响的假设。 (C) 2000 年生物精神病学协会。
Background: We examine whether traumatic events increase the risk for major depression independent of their effects on posttraumatic stress disorder (PTSD).Methods: Data come from the Epidemiologic Study of Young Adults in southeast Michigan (N = 1007). Retrospective and prospective data were used to estimate the risk of major depression in persons with PTSD and persons exposed to trauma with no PTSD, compared with persons who did not experience a trauma. National Comorbidity Survey data were used to evaluate the influence of trauma type.Results: In the retrospective lifetime data, hazard ratios were, for first-onset major depression in exposed persons with PTSD, 2.8 and, in exposed persons with no PTSD, 1.3 (not significant), as compared with persons who were not exposed. Corresponding estimates from the prospective data were 11.7 and 1.4 (not significant). The difference in the risk for depression associated with PTSD versus exposure without PTSD is unlikely to be due to differences in trauma type.Conclusions: The findings of a markedly increased risk for major depression in persons with PTSD, but not in exposed persons without PTSD, do not support the hypothesis that PTSD and major depression in trauma victims are influenced by separate vulnerabilities. (C) 2000 Society of Biological Psychiatry.