Genetic analysis of CR1 expression on erythrocytes of patients with systemic lupus erythematosus.
Genetic analysis of CR1 expression on erythrocytes of patients with systemic lupus erythematosus.
复制标题
系统性红斑狼疮患者红细胞CR1表达的基因分析
DOI：
--
复制
发表时间：
1989
影响因子：
--
通讯作者：
Michel D. Kazatchkine
中科院分区：
文献类型：
--
作者：
Jacques H. M. Cohen;Valérie Caudwell;Matthieu Levi;Pierre Bourgeois;Michel D. Kazatchkine
The role of genetic factors in decreased expression of CR1 in patients with systemic lupus erythematosus (SLE) was investigated by assessing the frequency of genotypes determining the numbers of CR1 on erythrocytes obtained from 52 patients with SLE and from 84 normal individuals. The expression of CR1 was quantitated using flow cytometry. Genotypes were determined by analyzing the CR1 gene restriction fragment length polymorphism using the CR1.1 complementary DNA probe and the Hind III restriction enzyme. In normal subjects, the distribution of the HH, HL, and LL genotypes fit the Hardy-Weinberg law. The frequency for the H allele did not differ between the 2 groups. No individual homozygous for the LL genotypes was found among the SLE patient population. Taken together, data from this and previous studies indicate an under-representation of the LL homozygous genotype in patients with SLE. SLE patients expressed decreased numbers of CR1 per erythrocyte within each genotype compared with these numbers in normal subjects. The results suggest that defective expression of CR1 in SLE patients is acquired and that the presence of the L allele is not linked to a genetic susceptibility for SLE.
登录
查看更多内容
影响因子：
4.4
作者：
J. G. Wilson;W. Wong;E. Murphy;P. Schur;D. Fearon
通讯作者：
J. G. Wilson;W. Wong;E. Murphy;P. Schur;D. Fearon
影响因子：
4.4
作者：
G. D. Ross;William J. Yount;M. Walport;J. Winfield;Charles J. Parker;C. Fuller;Ronald P. Taylor;B. Myones;Peter J. Lachmann
通讯作者：
G. D. Ross;William J. Yount;M. Walport;J. Winfield;Charles J. Parker;C. Fuller;Ronald P. Taylor;B. Myones;Peter J. Lachmann
补体受体表达改变作为系统性红斑狼疮的致病因素。
影响因子：
--
作者：
Wilson,JG;Fearon,DT
通讯作者：
Fearon,DT
系统性红斑狼疮患者的红细胞中存在针对 C3b/C4b 受体的自身抗体以及该受体的缺失。
DOI：
10.1172/jci111944
发表时间：
1985
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Wilson,JG;Jack,RM;Wong,WW;Schur,PH;Fearon,DT
通讯作者：
Fearon,DT
人类 C3b 受体。
DOI：
10.1007/bf00205871
发表时间：
1983
期刊：
Springer seminars in immunopathology
影响因子：
--
作者：
Fearon,DT
通讯作者：
Fearon,DT