Analysis of models for determining intestinal wall permeabilities.
Analysis of models for determining intestinal wall permeabilities.
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DOI：
10.1002/jps.2600691204
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发表时间：
1980-12
影响因子：
3.8
通讯作者：
G. Amidon;J. Kou;R. Elliott;E. Lightfoot
中科院分区：
文献类型：
--
作者：
G. Amidon;J. Kou;R. Elliott;E. Lightfoot
在测定肠壁通透性时，可以采用几种质量传递模型来分析外灌注实验的结果。任何给定模型的适当性取决于模型假设对实验系统的适用性。本报告比较了几种质量输运模型的假设和对特定实验设计的适用性。这些模型对灌注流体中的对流和扩散的假设有所不同。然而，由于壁面渗透率在每个模型中都是一个未知的参数，并且是从数据中估计出来的，所以所有的模型都能很好地拟合传质结果，尽管假设根本不同。然而，测定的渗透率不同。实验系统的停留时间分布分析对模型假设更为敏感。结果表明，在特定的实验系统中，圆柱管内的层流是最合适的模型。该模型还具有隐式计算灌注流体对流扩散问题的优点。因此，不能从数据中估计扩散层的厚度。有了流体力学的定义，就可以解释几种模型对数据的应用所得到的相对渗透率。用所建议的方法确定的壁渗透率提供了在完美混合条件下的极限辅助的估计。
In determining intestinal wall permeabilities, several mass transport models may be applied to analyze the results from external perfusion experiments. The appropriateness of any given model depends on the applicability of the model assumptions to the experimental system. This report compares several mass transport models with respect to their assumptions and applicability to a particular experimental design. The models are shown to differ in their assumptions regarding convection and diffusion in the perfusing fluid. However, since the wall permeability is an unknown parameter in each model and is estimated from the data, all of the models fit the mass transfer results reasonably well, despite fundamentally different assumptions. However, the determined permeabilities differ. Residence time distribution analysis of the experimental system is more sensitive to the model assumptions. It is shown that, in a particular experimental system, laminar flow in a cylindrical tube is the most appropriate model. The model also has the advantage of implicitly accounting for the convection-diffusion problem in the perfusing fluid. Hence, the diffusion layer thickness is not estimated from the data. With the hydrodynamics defined, the relative permeabilities resulting from the application of the several models to the data can be interpreted. The wall permeability determined in the suggested manner provides an estimate of the limiting assistance under perfect mixing conditions.