cGMP signalling in a transporting epithelium
cGMP signalling in a transporting epithelium
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DOI：
10.1042/bst0340512
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发表时间：
2006-08-01
影响因子：
3.9
通讯作者：
Day, J. P.
中科院分区：
文献类型：
--
作者：
Davies, S. -A.;Day, J. P.
cGMP信号传导的生物化学方面是众所周知的，尽管cGMP的体内作用最近才通过在遗传模型生物中的工作被发现。果蝇的malpighian（肾）小管已被用来解决的上皮功能中的cGMP的作用。在这里，我们描述了一些这方面的工作，并概述了最近的进展，了解器官型功能的新磷酸二酯酶编码的D。黑素细胞基因组。
The biochemical aspects of cGMP signalling are well known, although in vivo roles of cGMP have only been recently discovered through work in genetic model organisms. The Drosophila melanogaster malpighian (renal) tubule has been used to address the roles of cGMP in epithelial function. Here, we describe some of this work and outline recent progress in understanding the organotypic function of novel phosphodiesterases encoded by the D. melanogoster genome.