Detecting genetic effects on lipoprotein phenotypes in baboons: a review of methods and preliminary findings.
Detecting genetic effects on lipoprotein phenotypes in baboons: a review of methods and preliminary findings.
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检测狒狒脂蛋白表型的遗传效应：方法和初步发现的回顾。
DOI：
10.1007/bf00057446
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发表时间：
1987
期刊：
影响因子：
1.5
通讯作者：
McGillJr,HC
中科院分区：
文献类型：
--
作者：
MacCluer,JW;Kammerer,CM;VandeBerg,JL;Cheng,ML;Mott,GE;McGillJr,HC
检测主基因对数量表型贡献的统计方法在人类家系研究中得到了广泛的应用。回顾了这些方法中的一些方法，并描述了它们在人类疾病动物模型分析中的应用。对纯种狒狒的脂蛋白浓度的分析为特定脂蛋白成分的遗传效应提供了证据，这些脂蛋白成分与人类动脉粥样硬化的易感性降低有关。
Statistical methods for detecting the contribution of major genes to quantitative phenotypes have been widely applied in human family studies. Some of these methods are reviewed, and their application to analysis of an animal model for a human disease is described. Analysis of lipoprotein concentrations in pedigreed baboons provides evidence for genetic effects on specific lipoprotein components that have been associated with reduced susceptibility to atherosclerosis in humans.