Hemodynamic effects of intravenously administered magnesium on patients with ischemic heart disease
Hemodynamic effects of intravenously administered magnesium on patients with ischemic heart disease
复制标题
静脉注射镁对缺血性心脏病患者血流动力学的影响
DOI：
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发表时间：
1988
影响因子：
2.7
通讯作者：
Dr. H. Sandvad Rasmussen
中科院分区：
文献类型：
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作者：
M.D.. 0. G H. s. RASMUSSEN;M. K. Larsen;Res Meier;J. Nurse;M. D. Larsen;Dr. H. Sandvad Rasmussen
15例慢性缺血性心脏病和心力衰竭患者静脉注射12 mmoL氯化镁前后，右心导管记录中心血流动力学参数。血清镁浓度从0.76±0.03(平均值±SD)升高到1.5 4±0.0 5 mmo1/l，平均动脉压和肺动脉压分别下降10%(p<；0.0001)和7%(p<；0.05)。这是由于体循环和肺血管阻力显著降低(从1323±205降至1132±158dyn·S/cm~5，p<；0.001和从156±73降至133±72dyn·S/cm~5(p<；0.05)。心率、心脏指数、每搏量指数和每搏做功指数略有增加，尽管这些差异没有达到统计学意义。右室和左室充盈压没有受到影响，这表明在本研究中使用的剂量下，镁的扩张效应仅在血管床的动脉侧显著。观察到的镁输注的血流动力学效应可能通过减少左室后负荷而有益于急性心肌梗死的发生，这与镁的抗心律失常作用一起可能有助于镁输注对急性心肌梗死患者死亡率的积极影响。
Central hemodynamic parameters were registered by right‐side heart catheterization before and after intravenous administration of 12 mmol magnesium chloride (MgCl) in 15 patients with chronic ischemic heart disease and heart failure, New York Heart Association classes II and III. Serum magnesium concentrations increased from 0.76±0.03 (mean ± SD) to 1.54±0.05 mmol/1, which resulted in a reduction in mean arterial as well as pulmonary artery pressure by 10% (p<0.0001) and 7% (p<0.05), respectively. This reduction was caused by a marked decrease in systemic as well as pulmonary vascular resistance (from 1323 ±205 to 1132 ± 158 dyn•s/cm5, p<0.001 and from 156±73 to 133±72 dyn•s/cm5 (p<0.05). Heart rate, cardiac index, stroke volume index, and stroke work index increased slightly, although these differences did not reach statistical significance. Right and left ventricular filling pressures were not influenced, which indicates that the dilatory effect of magnesium, at the dosages used in the present study, is pronounced only at the arterial side of the vascular bed. The observed hemodynamic effects of the magnesium infusions may be beneficial in the setting of an acute myocardial infarction by reducing left ventricular afterload, which, together with the antiarrhythmic effect of magnesium may contribute to the positive effect of magnesium infusions on mortality in patients with acute myocardial infarction.