An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma.
An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma.
复制标题
DOI：
10.1155/2017/2480375
复制
发表时间：
2017
影响因子：
4.3
通讯作者：
Asakura A
中科院分区：
文献类型：
--
作者：
Hron AJ;Asakura A
横纹肌肉瘤（RMS）是一种侵袭性的软组织肿瘤家族，最常见于儿童。RMS变体表达几种骨骼肌标志物，表明RMS的肌源性干细胞或祖细胞起源。在这篇综述中，最近发现的和完善的microRNA在RMS中的作用进行了讨论，并以简洁的表格形式进行了总结。此外，RMS的亚型进行了审查沿着参与的基本螺旋-环-螺旋（bHLH）蛋白，Pax蛋白，和microRNA在正常和病理性肌发生。最后，目前和潜在的未来治疗方案RMS概述。
Rhabdomyosarcoma (RMS) is an aggressive family of soft tissue tumors that most commonly manifests in children. RMS variants express several skeletal muscle markers, suggesting myogenic stem or progenitor cell origin of RMS. In this review, the roles of both recently identified and well-established microRNAs in RMS are discussed and summarized in a succinct, tabulated format. Additionally, the subtypes of RMS are reviewed along with the involvement of basic helix-loop-helix (bHLH) proteins, Pax proteins, and microRNAs in normal and pathologic myogenesis. Finally, the current and potential future treatment options for RMS are outlined.